Journal: Journal of Pharmacy Research
Title: Antiurolithiatic potential of the fruit extracts of Carica papaya on ethylene glycol induced urolithiatic rats
Category: Pharmacology
Section: Research Article
- Abstract
- Audio Abstract
- Authors
- Pdf File
- Citation
- My Reference
- Methodology
-
Abstract
The fruit of Carica papaya Linn (Caricaceae) used in traditional medicine for the treatment of urinary stones. The present study was undertaken to evaluate the antiurolithatic effects of the aqueous and alcoholic extracts of the fruit of C. Papaya on ethylene glycol (EG) induced urolithiatic rats. EG administration resulted in hyperoxaluria as well as increased renal excretion of calcium and phosphate. Treatment with aqueous and alcoholic extracts of C. papaya fruit significantly reduced the elevated urinary oxalate, showing a regulatory action on endogenous oxalate synthesis. The increased deposition of stone forming constituents in the kidneys of calculogenic rats was also significantly lowered by curative and preventive treatment using aqueous and alcoholic extracts of the fruits of C. papaya. The results indicate that the fruit of C. papaya is endowed with antiurolithiatic activity and scientifically valid the traditional use of the fruit of C. Papaya in the treatment of urinary calculi.
-
Abstract Audio
About the authors and Affiliations
Author(s) Name: Khatib Nayeem*a, Dhaval Gupta a, Hashilkar Nayana b, Rajesh K. Joshi c
Affiliation(s) Name: a Department of Pharmacology, KLE College Of Pharmacy, KLE University Belgaum-590 010, Karnataka, India.
b Department of Pharmacology and Pharmacotherapeutics, J. N. Medical College, KLE University Belgaum-590 010 Karnataka, INDIA.
c Department of Phytochemistry, Regional Medical Research Centre, Indian Council of Medical Research, Nehru Nagar, Belgaum-590 010, Karnataka, India*Corresponding author.
Khatib Nayeem
Department of Pharmacology, KLE College Of Pharmacy, KLE University Belgaum-590 010,
Karnataka, India.Received on: 16-06-2010; Revised on: 15-08-2010; Accepted on:27-09-2010
-
View Article File in pdf format.
Article File
-
View Article Citation Here.
10 View More -
How to Cite my Article.
Author: Khatib Nayeem*a, Dhaval Gupta a, Hashilkar Nayana b, Rajesh K. Joshi c
Title: Antiurolithiatic potential of the fruit extracts of Carica papaya on ethylene glycol induced urolithiatic rats Journal: Journal of Pharmacy Research Vol(issue): 3 (November) Year: 2010 Page No: (2772-2775) -
Experimental Methods Keywords
Methodology: Antiurolithiatic potential, Hyperoxaluria, Kidney stone, Microcrystal, Renal damage Research Materials: Carica papaya
Keywords
Our Services
- Evaluation of Cardioprotective Role of Vinpocetine in Isoproterenol-induced Myocardial Infarction in Rats
- Solubility and Dissolution Enhancement: An overview
- A review on Calotropis procera Linn and its Ethnobotany, Phytochemical, Pharmacological profile
- Ethosomes: A novel tool for drug delivery through the skin
- Antimicrobial activity and phytochemical screening of five wild plants against Escherichia coli, Bacillus subtilis and Staphylococcus aureus
- A review on quality by design approach for analytical method development
- Development and Validation of Stability Indicating UV Spectrophotometric Method for the Estimation of Sitagliptin Phosphate in Bulk and Tablet Dosage Form
- Evaluation of Phenolic Content and Antioxidant Capacity of leaf extract from Phoenix Dactylifera L obtained by different pH of aqueous extraction
- Benzoic acid, one of the major components of aqueous bark extract of Terminalia arjuna protects against Copper-Ascorbate induced oxidative stress in human placental mitochondria through antioxidant m
- Zinc-silibinin complex ameliorates oxidative stress in high fat fed low dose STZ induced type 2 diabetes in rats
- Biological synthesis of silver nanoparticles using aqueous leaf extract of Capparis decidua (FORSK.) EDGEW: A better alternative
- Formulation and evaluation of topical gel of diclofenac sodium using different polymers
- Study of health related quality of life in rheumatoid arthritis patients
- In vitro antioxidant, anti-inflammatory and anticholinesterase activities of Rumex vesicarius L
- Antimicrobial activity of seaweeds Gracillaria, Padina and Sargassum sps. on clinical and phytopathogensSubba Rangaiah G, Lakshmi P* and Manjula E
- Antidiabetic activity of insulin plant (Costus igneus) leaf extract in diabetic rats
- Gastroprotective effect of Fenugreek 4-hydroxyisoleucine and trigonelline enriched fraction (TF4H (28%)) Sugaheal® against indomethacin induced ulcer in male wistar rats.
- Prescribing Patterns of antihypertensive drugs in a South Indian tertiary care hospital
- In vitro anti-Candida activity of Calotropis gigantea.
- Pharmacognostic, Phytochemical & Quantitative Investigation of Saraca asoca leaves
- Anti ulcer activity of Naravelia zeylanica leaves extract
- Melatonin affords protection against myocardial ischemia-induced cerebral mitochondrial dysfunction: an in vivo study.
- Synthesis and Biological Activity of Novel Acyl Hydrazone Derivatives of 3-(4,5-diphenyl-1,3-oxazol-2-yl) propanoic acid as Anticancer, Analgesic and Anti-inflammatory Agents
- Effects of Osmolytes on The Structural Stability of Bovine Trypsin: A Brief Review
- Design and Synthesis of Novel Quinazolinone Derivatives as Broad Spectrum Anticonvulsant and Antimicrobial Agent
- In vitro Antioxidant Activity from Leaves of Oroxylum indicum (L.) Vent. -A North Indian Highly Threatened and Vulnerable Medicinal Plant
- Genome of Acinetobacter baumannii Carries Multi Drug Resistance Genes
- Assessment of Pharmacognostical Characters of Leaves of Tephrosia Purpurea Linn
- Triazole analogues as novel antioxidants: In vitro bioassay and molecular modeling studies
- Anticonvulsant And Antioxidant Actions Of Some Dibenzo-a-Pyrone Derivatives In Pentylene –Induced Kindling Model In Mice