Journal: Journal of Pharmacy Research
Title: Antiurolithiatic potential of the fruit extracts of Carica papaya on ethylene glycol induced urolithiatic rats
Category: Pharmacology
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Abstract
The fruit of Carica papaya Linn (Caricaceae) used in traditional medicine for the treatment of urinary stones. The present study was undertaken to evaluate the antiurolithatic effects of the aqueous and alcoholic extracts of the fruit of C. Papaya on ethylene glycol (EG) induced urolithiatic rats. EG administration resulted in hyperoxaluria as well as increased renal excretion of calcium and phosphate. Treatment with aqueous and alcoholic extracts of C. papaya fruit significantly reduced the elevated urinary oxalate, showing a regulatory action on endogenous oxalate synthesis. The increased deposition of stone forming constituents in the kidneys of calculogenic rats was also significantly lowered by curative and preventive treatment using aqueous and alcoholic extracts of the fruits of C. papaya. The results indicate that the fruit of C. papaya is endowed with antiurolithiatic activity and scientifically valid the traditional use of the fruit of C. Papaya in the treatment of urinary calculi.
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About the authors and Affiliations
Author(s) Name: Khatib Nayeem*a, Dhaval Gupta a, Hashilkar Nayana b, Rajesh K. Joshi c
Affiliation(s) Name: a Department of Pharmacology, KLE College Of Pharmacy, KLE University Belgaum-590 010, Karnataka, India.
b Department of Pharmacology and Pharmacotherapeutics, J. N. Medical College, KLE University Belgaum-590 010 Karnataka, INDIA.
c Department of Phytochemistry, Regional Medical Research Centre, Indian Council of Medical Research, Nehru Nagar, Belgaum-590 010, Karnataka, India*Corresponding author.
Khatib Nayeem
Department of Pharmacology, KLE College Of Pharmacy, KLE University Belgaum-590 010,
Karnataka, India.Received on: 16-06-2010; Revised on: 15-08-2010; Accepted on:27-09-2010
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Author: Khatib Nayeem*a, Dhaval Gupta a, Hashilkar Nayana b, Rajesh K. Joshi c
Title: Antiurolithiatic potential of the fruit extracts of Carica papaya on ethylene glycol induced urolithiatic rats Journal: Journal of Pharmacy Research Vol(issue): 3 (November) Year: 2010 Page No: (2772-2775) -
Experimental Methods Keywords
Methodology: Antiurolithiatic potential, Hyperoxaluria, Kidney stone, Microcrystal, Renal damage Research Materials: Carica papaya
Keywords
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