Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-0000140
Title: Synthesis and antifungal activity studies of novel 3,4,5-trisubstitutedisoxazole derivatives
Category: Pharmaceutical Chemistry
Section: Research Article
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  • Abstract

    Novel 3,4,5-trisubstituedisoxazole derivatives were prepared by multi step synthesis. We have prepared two set of derivatives, in the first set 3,5-diarylisoxazole-4-carboxamide derivative and in the second set 3,5-diaryisoxazole-4-methyamine derivatives were prepared. The structures of the newly synthesized compounds are characterized by 1HNMR, 13C NMR, LC-MS and screened for their antifungal activity against Aspergillus flavus (NCIM No.524), Fusarium oxysporum (NCIM No.1072) and Candida albicans (NCIM No.3102).

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  • About the authors and Affiliations

    Author(s) Name:

    Rajesha Shetty1*, S. Syed Shafi2, Yuvaraj. K1,

    Affiliation(s) Name:

    1Department of Chemistry, Islamiah College, Vaniyambadi - 635 751, Tamil Nadu, India.
    2Department of Chemistry, Thiruvalluvar university, Vellore - 632106, Tamil Nadu, India.


    *Corresponding author.
    Rajesha Shetty
    Department of Chemistry,
    Islamiah College,
    Vaniyambadi - 635 751,
    Tamil Nadu, India.


    Received on:02-02-2014; Revised on: 04-03-2014; Accepted on:07-03-2014

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    Author:

    Rajesha Shetty1*, S. Syed Shafi2, Yuvaraj. K1,

    Title:Synthesis and antifungal activity studies of novel 3,4,5-trisubstitutedisoxazole derivatives
    Journal:Journal of Pharmacy Research
    Vol(issue):8 (March)
    Year:2014
    Page No: (289-295)
  • Experimental Methods Keywords

    Methodology:synthesis, Antifungal activity
    Research Materials:3,4,5-trisubstitutedisoxazole derivatives

Keywords

Isoxazole 3-(2 4-difluorophenyl)-N-(4-methoxybenzyl)-5-phenylisoxazole-4-carboxamide Synthesis Antifungal activity

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