Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001405
Title: Antihyperglycaemic Activity of Ethanol Extract of Aerva javanica Leaves in Alloxan- Induced Diabetic Mice
Category: Pharmacology
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    The antihyperglycaemic activity of ethanol extract of Aerva javanica (EEAJ) leaves was studied by administering three doses of EEAJ (i.e. 100,200 and 400 mg/kg, p.o.) and glyburide (10 mg/kg) to alloxan (70 mg/kg, i.v.) induced diabetic mice. The serum glucose levels and body weights of mice were determined. In acute study the maximum reduction in serum glucose level was observed at 2h, peak at 6h but antihyperglycaemic effect was vanished at 24h. The sub acute study was also carried out which showed maximum reduction in serum glucose level at the dose of 400 mg/kg on 35th day. EEAJ (400 mg/kg) showed increased glucose threshold in non-diabetic and diabetic mice at 60 min after administration of glucose. EEAJ (400 mg/kg) prevented the loss of body weight. The EEAJ (400 mg/kg) showed significantly more hyperglycaemic activity than EEAJ (100 and 200 mg/kg).

  • Abstract Audio

    Click Here

  • About the authors and Affiliations

    Author(s) Name:

    Srinivas Reddy. K*, Reddy. V. M.

    Affiliation(s) Name:

    *Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda, warangal 506001, AP, India

    Received on: 27-02-2009; Accepted on: 29-04-2009

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    7 View More
  • How to Cite my Article.

    Author:

    Srinivas Reddy. K*, Reddy. V. M.

    Title:Antihyperglycaemic Activity of Ethanol Extract of Aerva javanica Leaves in Alloxan- Induced Diabetic Mice
    Journal:Journal of Pharmacy Research
    Vol(issue):2(7)
    Year:2009
    Page No: (1259-1261)
  • Experimental Methods Keywords

    Methodology:Alloxan-induced, Antihyperglycaemic, Body weight, OGTT.
    Research Materials:Aerva javanica

Keywords

Aerva javanica Alloxan-induced Antihyperglycaemic Body weight OGTT.

Our Services

Most Downloaded List