Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00001407
Title: RP-HPLC determination of vildagliptin in pure and in tablet formulation
Category: Pharmaceutics
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    Aim: The present work aims to a simple, rapid and reproducible reverse phase high performance liquid chromatographic (RP-HPLC) method for the estimation of vildagliptin in pure form and in tablet dosage form using Agilent XDB C18, 150  4.6 mm, 5 mm, column. Methods: The mobile phase consists of 0.1 M Phosphate buffer and acetonitrile in the ratio of 85:15% v/v, and was pumped at rate of 1.0 mL/min. The detection was carried out at 210 nm and the calibration curve was linear in the concentration range of 10e150 mg/mL. Results: The method was statistically validated for its linearity, precision, accuracy, stability, specificity, LOD and LOQ. Due to its simplicity, rapidness, high precision and accuracy, the proposed RP-HPLC method may be used for determining vildagliptin in pure form and in tablet formulation. Conclusion: The proposed method was found to be simple, precise, accurate and rapid for determination of vildagliptin from pure form and tablet dosage form.

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    Author(s) Name:

    Thangabalan Boovizhikannan a,b,*, Vijayaraj Kumar Palanirajan c

    Affiliation(s) Name:

    a Department of Pharmaceutical Analysis, Southern Institute of Medical Sciences, College of Pharmacy, Vijayawada Road, Mangaldas Nagar,
    Guntur 522 001, Andhra Pradesh, India
    b Department of Science and Technology, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad 500 085,
    Andhra Pradesh, India
    c Faculty of Pharmaceutical Sciences, UCSI University, No.1 Jalan Menara Gading 56000 Cheras, Kuala Lumpur, Malaysia

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    Author:

    Thangabalan Boovizhikannan a,b,*, Vijayaraj Kumar Palanirajan c

    Title:RP-HPLC determination of vildagliptin in pure and in tablet formulation
    Journal:Journal of Pharmacy Research
    Vol(issue):7 (January )
    Year:2013
    Page No: (113-116)
  • Experimental Methods Keywords

    Methodology:RP-HPLC methods
    Research Materials:Vildagliptin

Keywords

Vildagliptin RP-HPLC Tablets

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