Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-00001409
Title: Synthesis and Anti-Inflammatory Activity of Some 5-Phenyl-1-(Acyl)-1, 2, 3, 4-Tetrazole.
Category: Pharmaceutical Chemistry
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  • Abstract

    A series of novel 5-phenyl,1-acyl 1,2,3,4-tetrazoles (3–10) have been synthesized via condensation of 5-phenyl-1,2,3,4-tetrazoles (2) with various acylating reagents. 5-phenyl- 1,2,3,4-tetrazoles was synthesized by the cycloaddition of Benzonitrile(1) with sodium azide and ammonium chloride in presence of Dimethylformamide as solvent. All synthesized compounds which were characterized to be new substituted Tetrazoles. Their structures were determined by 1H NMR,FT-IR, mass spectra and elemental analyses. The compounds synthesized were screened for anti-inflammatory activity. Compounds 4, 7 and 9 possess potent anti-inflammatory activity.

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    Author(s) Name:

    Popat B. Mohite*1, Ramdas B.Pandhare1, Shantaram G.Khanage, 1 Vaidhun H. Bhaskar2.

    Affiliation(s) Name:

    1MES College of Pharmacy, Sonai,Ahmednagar,Maharashtra,India
    2MP Patel College of Pharmacy,Kapadwanj, Gujrat,India.

    *Corresponding author.
    Mr.Popat B.Mohite
    MES College of Pharmacy, Sonai
    Tel-Newasa, Dist-Ahmednagar
    Maharashtra-414105 India

    Received on: 20-09-2009; Revised  on: 09-10-2009; Accepted on:12-12-2009

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    Author:

    Popat B. Mohite*1, Ramdas B.Pandhare1, Shantaram G.Khanage, 1 Vaidhun H. Bhaskar2.

    Title:Synthesis and Anti-Inflammatory Activity of Some 5-Phenyl-1-(Acyl)-1, 2, 3, 4-Tetrazole.
    Journal:Journal of Pharmacy Research
    Vol(issue):3(1)
    Year:2010
    Page No: (43-46)
  • Experimental Methods Keywords

    Methodology:Synthesis and Anti-Inflammatory Activity
    Research Materials: 5-Phenyl-1-(Acyl)-1, 2, 3, 4-Tetrazole

Keywords

Tetrazoles Dimethylformamide Benzonitrile. Anti-inflammatory activity

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