Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-0000144
Title: Melatonin protects against lead acetate-induced changes in blood corpuscles and lipid profile of male Wistar rats
Category: Pharmacology
Section: Research Article
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  • Abstract

    Treatment of rats with lead acetate at a dose of 15 mg / kg body weight intraperitoneally (i.p) for a period of seven consecutive days caused alterations in the total count of erythrocyte, total count of leukocyte, hemoglobin content, mean corpuscular hemoglobin content, neutrophil count, small lymphocyte count, eosinophil count, erythrocyte sedimentation rate (ESR), total cholesterol, triglyceride, HDL cholesterol, LDL cholesterol, Total cholesterol: HDL cholesterol, LDL cholesterol :HDL cholesterol. All these changes were ameliorated when the rats were pre-treated with melatonin at a dose of 10 mg / kg (fed orally) for a similar period of time. The results of the current studies indicate melatonin’s ability to mitigate heavy metal-induced alterations in blood tissue. This is probably brought about through the antioxidant activity of melatonin and may have future therapeutic relevance in humans exposed to lead environmentally or occupationally and in situations where chelation therapy has limited success.

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    Author(s) Name:

    Debosree Ghosh1, Monalisa Dey1, Arnab Kumar Ghosh1, Aindrila Chattopadhyay2 and Debasish Bandyopadhyay1*#

    Affiliation(s) Name:

    1Department of Physiology, Oxidative Stress and Free Radical Biology Laboratory, University of Calcutta, University College of Science and Technology, 92, APC Road, Kolkata 700 009 India.
    #Principal Investigator, Centre with Potential for Excellence in a Particular Area (CPEPA), University of Calcutta, University College of Science and Technology, 92 APC Road, Kolkata 700 009 India.
    2Department of Physiology, Vidyasagar College, 39, Shankar Ghosh Lane,Kolkata 700006, India.

    *Corresponding author.
    Dr. Debasish Bandyopadhyay
    Oxidative Stress and Free Radical Biology Laboratory,
    Department of Physiology, University of Calcutta
    University College of Science and Technology
    92, APC Road, Kolkata 700 009 India


    Received on:21-02-2014; Revised on:01-03-2014; Accepted on:07-03-2014

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    Author:

    Debosree Ghosh1, Monalisa Dey1, Arnab Kumar Ghosh1, Aindrila Chattopadhyay2 and Debasish Bandyopadhyay1*#
    Title:Melatonin protects against lead acetate-induced changes in blood corpuscles and lipid profile of male Wistar rats
    Journal:Journal of Pharmacy Research
    Vol(issue):8 (March)
    Year:2014
    Page No: (336-342)

  • Experimental Methods Keywords

    Methodology:Estimation of RBC total count,Estimation of white blood cell (WBC) total count,Determination of hemoglobin content per red blood cell (MCH),Estimation of lymphocytes and neutrophil count,Estimation of
    Research Materials:Melatonin

Keywords

Melatonin blood antioxidant lead acetate LDL HDL Cholesterol ESR

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