Journal: Journal of Pharmacy Research
Title: In vitro radical scavenging activity and phytochemical screening for evaluation of the antioxidant potential of Operculina turpethum root extract
Category: Natural Drugs
Section: Research Article
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Abstract
Cellular damage or oxidative injury arising from free radicals or reactive oxygen species (ROS) now appears the fundamental mechanism underlying a number of human neurodegenerative disorders, diabetes, inflammation, viral infections, autoimmune pathologies and digestive system disorders. Naturally occurring antioxidant supplements from plants are vital to counter the oxidative damage in cells. We assessed the antioxidant potential and phytochemical constituents of ethanolic extract of Operculina turpethum using tests involving inhibition of H2O2, superoxide anions, reducing power and FRAP . The phenolic, flavonoid and proanthocyanidin contents of the extract were also determined using standard phytochemical reaction methods. The results of the assay were then compared with natural antioxidants Quercitin, rutin and BHA. On the basis of present investigation the extract showed high significance (p<0.001) as compared to standards. Operculina turpethum extract showed the presence of alkaloids, carbohydrates, saponins, flavonoids and cardiac glycosides. A positive correlation between the antioxidant activities and physiochemical assays was observed and the highest scavenging activity of extract was noticed at concentration of 1mg/ml.. These finding suggest that this plant is a potential source of natural antioxidant that could serve as free radical inhibitors or scavenger, could have great importance as therapeutic agents, anti-inflammatory, anti-analgesic, anti-anaemic, in preventing or slowing the progress of ageing and age associated oxidative stress related degenerative diseases such as cancer and various other human ailments.
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About the authors and Affiliations
Author(s) Name: Veena Sharma* and Manu Singh
Affiliation(s) Name: Department of Bioscience and Biotechnology, Banasthali University, Banasthali 304022, Rajasthan, India
*Corresponding author.
Dr. Veena Sharma
Department of Bioscience and Biotechnology,
Banasthali University, Banasthali 304022,
Rajasthan, IndiaReceived on:10-11-2011; Revised on: 15-12-2011; Accepted on:12-01-2012
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Author: Veena Sharma* and Manu Singh
Title: In vitro radical scavenging activity and phytochemical screening for evaluation of the antioxidant potential of Operculina turpethum root extract Journal: Journal of Pharmacy Research Vol(issue): 5 (February) Year: 2012 Page No: (783-787) -
Experimental Methods Keywords
Methodology: Anticancer, Antioxidant, BHA, FRAP Research Materials: Operculina turpethum
Keywords
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