Journal: Journal of Pharmacy Research

Article Id: JPRS-BMB-00001467
Title: Preventive effect of esculetin on lipid peroxides and antioxidants in isoproterenol-induced myocardial infarction in Wistar rats
Category: Biochemistry and Molecular Biology
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    The present study is undertaken to evaluate the effect of esculetin on the levels of lipid peroxidation and antioxidants in isoproterenol (ISO)-induced myocardial infarction (MI) in Wistar rats. The rats were subcutaneously injected with isoproterenol (ISO) (85 mg/kg) at an interval of 24 hours for two days. A significant increased in the levels of thiobarbituric acid reactive substances (TBARS) and hydroperoxide (HP), whereas the activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase, glutathione-S-transferase (GST), glutathione peroxidase (GPx) and non-enzymatic antioxidants like reduced glutathione (GSH), vitamin E & C were significantly decreased. Oral pretreatment with esculetin (10 and 20 mg/kg) to ISO-induced rats daily for a period of 21 days significantly decreased the levels of TBARS and HP also increased the levels of both enzymatic and non-enzymatic antioxidant. This could be due to free radical scavenging and antioxidant property of esculetin. Thus, our finding demonstrates that esculetin prevents the alterations in lipid peroxidation and antioxidants status during ISO-induced MI in rats.

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    Author(s) Name:

    Palanivel Karthika, Murugan Rajadurai *, Palanisamy Ganapathy, Ganesan Kanchana.

    Affiliation(s) Name:

    Department of Biochemistry, Muthayammal College of Arts & Science, Rasipuram - 637 408, Tamil Nadu, India.

    *Corresponding author.
    Dr. M. Rajadurai,
    Assistant Professor,
    Department of Biochemistry,
    Muthayammal College of Arts & Science,
    Rasipuram- 637408, Namakkal,
    Tamil Nadu, India

    Received on:10-11-2011; Revised  on: 15-12-2011; Accepted on:12-01-2012

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    Author:

    Palanivel Karthika, Murugan Rajadurai *, Palanisamy Ganapathy, Ganesan Kanchana.

    Title:Preventive effect of esculetin on lipid peroxides and antioxidants in isoproterenol-induced myocardial infarction in Wistar rats
    Journal:Journal of Pharmacy Research
    Vol(issue):5 (February)
    Year:2012
    Page No: (915-918)
  • Experimental Methods Keywords

    Methodology:myocardial infarction; lipid peroxidation; antioxidants.
    Research Materials:Esculetin; isoproterenol

Keywords

Esculetin; isoproterenol; myocardial infarction; lipid peroxidation; antioxidants.

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