Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-00001469
Title: Synthesis and evaluation of carrier linked Prodrug of Ketoprofen with Glucosamine
Category: Pharmaceutical Chemistry
Section: Research Article
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    Nonsteroidal anti-inflammatory drugs are widely used to treat the effects of inflammation through inhibition of cyclooxygenase enzyme. The major limitation to long term therapeutic use of these drugs is their gastro toxicity. The Prodrug approach can be applied to solve this problem, which is an established tool to mask the side-effects of drugs. The present work was targeted at the designing of carrier linked prodrug of Ketoprofen with glucosamine by masking the free carboxyl group. The synthesized prodrug was characterized by analytical and spectral data. The synthesized prodrug was also evaluated for its anti-inflammatory activity and ulcerogenic potential. It exhibited increase in anti-inflammatory activity and significantly less ulcerogenic ability than parent drug.

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    Author(s) Name:

    Patil Smita J.*1, Shirote Pramod J.2

    Affiliation(s) Name:

    M. Pharm, Asst. Professor, Santkrupa College of Pharmacy, Ghogaon. Tal –Karad, Dist – Satara. Pin-415 103 (M.S., India.)
    PhD, H.O.D., Department of Pharmaceutical Chemistry, Appasaheb Birnale College of Pharmacy, Sangli- 416 416. (M.S., India.)

    *Corresponding author.
    Ms. Patil Smita J.
    C/O Patil Rajendra Bhagwan.
    Mahalaxmi Jwellers, Kusur,  
    Tal. - Karad, Dist. - Satara,
    MaharashtraPin– 415 103,

    Received on:10-11-2011; Revised on: 15-12-2011; Accepted on:12-01-2012

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    Patil Smita J.*1, Shirote Pramod J.2

    Title:Synthesis and evaluation of carrier linked Prodrug of Ketoprofen with Glucosamine
    Journal:Journal of Pharmacy Research
    Vol(issue):5 (February)
    Page No: (954-957)
  • Experimental Methods Keywords

    Methodology:Synthesis and evaluation, ulcerogenicity, anti-inflammatory activity.
    Research Materials:Ketoprofen, glucosamine


Prodrug NSAID Ketoprofen glucosamine ulcerogenicity anti-inflammatory activity.

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