Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00001473
Title: Formulation Development and Evaluation of Risperidone Fast Dissolving Tablets
Category: Pharmaceutics
Section: Research Article
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    Background:The main aim of present research investigation is to formulate the Risperidone Fast Dissolving tablets. Risperidone, an atypical antipsychotic, belongs to BCS Class-II and used for treating schizophrenia, bipolar mania and autism by blocking D2 and 5-HT2A receptors. Methods: The Fast Dissolving tablets of Risperidone were prepared employing different concentrations of Crospovidone and Croscarmellose sodium in different combinations as a Superdisintegrants by Direct Compression technique using 32 factorial design. The  concentration of Crospovidone and Croscarmellose sodium was selected as independent variables, X1 and X2 respectively whereas, wetting time, Disintegration time, t50% ,t90%were selected as dependent variables.  Results and Discussion: Totally nine formulations were designed, preapred and are evaluated for hardness, friability, thickness, Assay, Wetting time, Disintegration time, In-vitro drug release. From the Results concluded that all the formulation were found to be with in the Pharmacopoeial limits and  the In-vitro dissolution profiles of all formulations were fitted in to different Kinetic models, the statistical parameters like intercept (a), slope (b) & regression coefficient (r)  were calculated. Polynomial equations were developed for Wetting time, Disintegration time, t50%, t90%.  Validity of developed polynomial equations were verified by designing 2 check point formulations (C1, C2). According to SUPAC guidelines the formulation (F5) containing combination of 10% Crospovidone and 10% Croscarmellose, is the most similar formulation (similarity factor f2= 93.556, dissimilarity factor f1= 0.976 & No significant difference, t= 0.022) to marketed product (RISPERDAL-4).  Conclusion:The selected formulation (F5) follows First order, Higuchi’s kinetics, mechanism of drug release was found to be Fickian Diffusion (n= 0.383).

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    Author(s) Name:

    Raghavendra Kumar Gunda*1, J.N.Suresh Kumar1, S.Jayakumari2, A.Vijayalakshmi 2, V.Satyanarayana3

    Affiliation(s) Name:

    1Department of Pharmaceutics, Narasaraopeta Institute of Pharmaceutical Sciences, Narasaraopet, Guntur (Dt), Andhra Pradesh, India-522601.
    2Department of Pharmacognosy, School of Pharmaceutical Sciences, VISTAS, VELs University, Pallavaram, Chennai,Tamilnadu,India- 600117.
    3Department of Pharmacy Practice, Narasaraopeta Institute of Pharmaceutical Sciences, Narasaraopet, Guntur (Dt), Andhra Pradesh, India-522601.

    *Corresponding author.
    Mr.Raghavendra Kumar Gunda  M.Pharm
    Assistant Professor, Department of Pharmaceutics,
    Narasaraopeta Institute of Pharmaceutical Sciences,
    Narasaraopet, Guntur(D.t), A.P. India-522601.

    Received on:08-06-2016; Revised on: 20-07-2016; Accepted on: 14-09-2016

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    Author:

    Raghavendra Kumar Gunda*1, J.N.Suresh Kumar1, S.Jayakumari2, A.Vijayalakshmi 2, V.Satyanarayana3

    Title:Formulation Development and Evaluation of Risperidone Fast Dissolving Tablets
    Journal:Journal of Pharmacy Research
    Vol(issue):10 (September)
    Year:2016
    Page No: (579-588)
  • Experimental Methods Keywords

    Methodology:32 Factorial Design, Wetting Time, Disintegration Time.
    Research Materials:Risperidone,Crospovidone ,Croscarmellose Sodium,

Keywords

Risperidone 32 Factorial Design Crospovidone Croscarmellose Sodium Wetting Time Disintegration Time.

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