Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-00001475
Title: Novel synthetic molecule inhibits Protein Tyrosine Phosphatase 1B (PTP1B) for anti-hyperglycemia: Investigation by Molecular Docking Approach
Category: Pharmaceutical Chemistry
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  • Abstract

    Synthetic molecule (RBMS-01) was investigated as an inhibitor of human PTP1B in an attempt to explain its anti-hyperglycemic activity.  The investigation included molecular docking experiments to fit the synthetic molecule within the binding pocket of PTP1B.  This novel compound was found to readily fit within the binding pocket of h-PTP1B in a low energy orientation characterized with optimal electrostatic attractive interactions bridging the quinoline positively charged nitrogen atom of the synthetic molecule.  Then, the comparative studies with other natural compounds were analyzed.  Our findings strongly suggest that PTP1B inhibition is at least one of the reasons for the reported anti-hyperglycemic activities of the novel synthetic molecule.

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    Author(s) Name:

    R.  Balajee1*, M. S. DhanaRajan2

    Affiliation(s) Name:

    1 Research Scholar, Sathyabama University, Chennai 119., Tamil Nadu, India
    2 Principal, Jaya College of Arts and Science, Thiruninravur,Tamil Nadu, India

    *Corresponding author.
    R.  Balajee
    Research Scholar,
    Sathyabama University,
    Chennai 119,
    Tamil Nadu,India

    Received on:10-11-2011; Revised  on: 15-12-2011; Accepted on:12-01-2012

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    Author:

    R.  Balajee1*, M. S. DhanaRajan2

    Title:Novel synthetic molecule inhibits Protein Tyrosine Phosphatase 1B (PTP1B) for anti-hyperglycemia: Investigation by Molecular Docking Approach
    Journal:Journal of Pharmacy Research
    Vol(issue):5 (February)
    Year:2012
    Page No: (968-973)
  • Experimental Methods Keywords

    Methodology:anti-hyperglycemic activity, Catalytic Site
    Research Materials: PTP1B, quinoline derivative

Keywords

PTP1B anti-hyperglycemic activity Catalytic Site quinoline derivative

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