Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00001476
Title: Crystal Modification of Aceclofenac by Spherical Crystallization to Improve Solubility Dissolution Rate and Micromeritic Properties
Category: Pharmaceutics
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    Aceclofenac a non-steroidal anti-inflammatory drug widely used in the treatment of rheumatoid arthritis. The poor water solubility and poor micromeritic properties of aceclofenac lead to low dissolution rate and poor flow during tableting. The aim of present study was to improve dissolution rate and micromeritic properties of aceclofenac by spherical agglomeration techniques. The spherical agglomerate of aceclofenac was carried out by solvent change method in the presence of hydrophilic polymer in different concentration. The solvent system used was acetone, water and dichloromethane as good solvent, anti-solvent and bridging liquid respectively. The spherical agglomerates were characterized by FTIR spectroscopy, scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and X-ray diffraction (XRD) studies. Also the agglomerates were evaluated for dissolution rate and micromeritic properties. The FTIR and DSC study showed no interaction between drug and polymer. XRD studies showed a slight decrease in crystallinity in agglomerates. The agglomerate showed significantly improved dissolution rate as well as micromeritic properties compared to pure drug. The SEM also showed that the agglomerate possess a good spherical shape.

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    Author(s) Name:

    R. R. Thenge*

    Affiliation(s) Name:

    Department of Pharmaceutics, IBSS College of Pharmacy, Malkapur-443101, Maharashtra, India

    *Corresponding author.
    R. R. Thenge
    Department of Pharmaceutics,
    IBSS College of Pharmacy,
    Malkapur-443101,
     Maharashtra, India.

    Received on:10-11-2011; Revised  on: 15-12-2011; Accepted on:12-01-2012

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    Author:

    R. R. Thenge*

    Title:Crystal Modification of Aceclofenac by Spherical Crystallization to Improve Solubility Dissolution Rate and Micromeritic Properties
    Journal:Journal of Pharmacy Research
    Vol(issue):5(2)
    Year:2012
    Page No: (974-977)
  • Experimental Methods Keywords

    Methodology:Spherical Crystallization , spherical agglomerate, solubility, dissolution, micromeritic properties
    Research Materials:Aceclofenac

Keywords

Aceclofenac spherical agglomerate solubility dissolution micromeritic properties

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