Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00001477
Title: Solid dispersion a new horizen in novel drug delivery system
Category: Pharmaceutics
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  • Abstract

    The enhancement of dissolution rate and oral bioavailability is one of the greatest challenges in the development of poorly water soluble drugs. So, solid dispersion is an efficient tool for increasing the oral bioavailability and dissolution rate of a range of hydrophobic drugs. Solid dispersion is used to produce a homogeneous distribution of a small amount of drug in solid state. This article reviews the various preparation techniques of solid dispersion and compiles some of the recent technologies. This article summarize some of the practical aspects for the preparation of solid dispersion like selection of carrier ,method of physicochemical characterization, their advantages, limitations and applications along with an insight into the molecular arrangement of drug in solid dispersion. Solid dispersion technique is widely used to study various approaches and applications of drug properties and polymers used in pharmaceutical research. Hence, solid dispersion is a very useful method for pharmaceutical point of view because of its capability to solve the solubility problems by using solid dispersion method.

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  • About the authors and Affiliations

    Author(s) Name:

    Dr. Devender Singh Rathore, Reeta Rani Thakur, Sonia Narwal

    Affiliation(s) Name:

    M.M. College Of Pharmacy, M.M. University,Mullana, Ambala-133207, India

    *Corresponding author.
    Reeta Rani Thakur
    Assistant Professor
    M.M. College Of Pharmacy,
    M.M. University
    Mullana, Ambala-133207, India


    Received on:10-11-2011; Revised  on: 15-12-2011; Accepted on:12-01-2012

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    Author:

    Dr. Devender Singh Rathore, Reeta Rani Thakur, Sonia Narwal

    Title:Solid dispersion a new horizen in novel drug delivery system
    Journal:Journal of Pharmacy Research
    Vol(issue):5(2)
    Year:2012
    Page No: (1007-1014)
  • Experimental Methods Keywords

    Methodology: bioavailability, solubility, dissolution, fusion, solvent evaporation, spray drying.
    Research Materials:solid product

Keywords

solid dispersion hydrophilic matrix bioavailability solubility dissolution fusion solvent evaporation spray drying.

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