Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-00001478
Title: Effective quantitation of Acetaminophen, Phenylephrine hydrochloride, Cetirizine hydrochloride and Caffeine in pharmaceutical dosage form using UV spectroscopy
Category: Pharmaceutical Chemistry
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  • Abstract

    Attempting to minimize the drawbacks of various organic solvents commonly used for solublization, two new spectrophotometric methods have been developed for simultaneous determination of acetaminophen, phenylephrine hydrochloride, cetirizine hydrochloride and caffeine in pure and tablet dosage form by using 0.1N NaOH. Jasco V-630 sepctrophotometer is used for quantitation.  Without resolving mixtures of acetaminophen, phenylephrine hydrochloride, cetrizine hydrochloride and caffeine, simultaneous estimation has been successfully achieved by spectrophotometry. Method I employ formation and solving of mathematical simultaneous equation using 259 nm, 233 nm, 231 nm and 273 nm as the lmax of acetaminophen, phenylephrine hydrochloride, cetirizine hydrochloride and caffeine respectively. Method II is a multiwavelength spectrophotometric analysis in which the instrument is preprogrammed to collect and compile the spectral data from the scan of standards and matrix calculations. These methods were validated for accuracy, precision, linearity, specificity and sensitivity as per ICH norms. Calibration curves were linear over the concentration ranges of 0-40 ìg/mL for all drugs. The validation study is statistically significant as all the statistical parameters are within the acceptance range (% COV< 2.0 and S.D. < 2.0) for both accuracy and precision. Both the methods are successfully applied to pharmaceutical formulation, with no interference from excipients as indicated by the recovery study. The proposed methods are simple, rapid, economic and accurate for routine simultaneous estimation of acetaminophen, phenylephrine hydrochloride, cetirizine hydrochloride and caffeine.

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    Author(s) Name:

    Rupali Joshi*, Nilima Pawar, Umesh Dongre, Sameer Katiyar

    Affiliation(s) Name:

    Pharmaceutical Chemistry Department, P.D.V.V.P.F’s College of Pharmacy, Vilad – Ghat,Post MIDC, Ahmednagar(M.S.)-414111, India

    *Corresponding author.
    Rupali Joshi
    Pharmaceutical Chemistry Department, P.D.V.V.P.F’s College of Pharmacy,
    Vilad – Ghat,Post MIDC,
    Ahmednagar(M.S.) India 414111


    Received on:10-11-2011; Revised  on: 15-12-2011; Accepted on:12-01-2012

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    Author:

    Rupali Joshi*, Nilima Pawar, Umesh Dongre, Sameer Katiyar

    Title:Effective quantitation of Acetaminophen, Phenylephrine hydrochloride, Cetirizine hydrochloride and Caffeine in pharmaceutical dosage form using UV spectroscopy
    Journal:Journal of Pharmacy Research
    Vol(issue):5(2)
    Year:2012
    Page No: (1018-1021)
  • Experimental Methods Keywords

    Methodology: Simultaneous Equation Method, Multi-Wavelength Method
    Research Materials:Acetaminophen, Phenylephrine Hydrochloride, Cetirizine Hydrochloride, Caffeine

Keywords

Acetaminophen Phenylephrine Hydrochloride Cetirizine Hydrochloride Caffeine Simultaneous Equation Method Multi-Wavelength Method.

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