Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00001480
Title: Formulation and evaluation of lamivudine sustained release matrix tablets using synthetic polymers
Category: Pharmaceutics
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  • Abstract

    The present investigation is aimed at formulating and evaluating sustained release matrix tablets of Lamivudine using different synthetic polymers such as Hydroxypropylmethylcellulose (HPMC K4M), Ethyl cellulose and Methyl cellulose taken at 10%, 20% and 30% of the total weight of the tablet. Lamivudine is a potent hydrophilic anti viral agent indicated for treatment of AIDS (Acquired Immunodeficiency Syndrome). The sustained release tablets were prepared by direct compression method. The powders for tableting were evaluated for angle of repose, loose bulk density, tapped bulk density, compressibility index and hausner’s ratio etc.The powder blend showed satisfactory flow properties.The tablets were subjected to thickness, weight variation test, drug content, hardness, friability and in-vitro release studies. All the formulations showed good results which were compliance with Pharmacopoeial standards.  In-vitro drug release studies were carried out using USP dissolution apparatus type I at 100 rpm with 900 ml phosphate buffer solutions (PBS) of pH 6.8, maintained at 37±0.5°C. The release kinetics was analyzed using the zero-order, first-order model equation, higuchi’s square-root equation, and the Korsmeyer-peppas model.  In vitro release studies revealed that the release rate decreased with increases in polymer proportion. The sustained release matrix tablets containing 30% Hydroxypropylmethylcellulose (HPMC K4M) (Formulation LF3) were found to show good initial release (20.41% in two hours) and extended the release upto 12 hours and can overcome the disadvantages of conventional tablets of Lamivudine. The n value obtained from korsmeyer – Peppas model confirmed that the drug release was non- fickian diffusion mechanism.

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  • About the authors and Affiliations

    Author(s) Name:

    Shanmugam S, Kamaraj K* and  Vetrichelvan T

    Affiliation(s) Name:

    Adhiparasakthi College of  Pharmacy, Melmaruvathur-603 319, Tamil Nadu, India.

    *Corresponding author.
    Shanmugam S, Kamaraj K
    Adhiparasakthi College of  Pharmacy, Melmaruvathur-603 319,
    Tamil Nadu, India.

    Received on:10-11-2011; Revised  on: 15-12-2011; Accepted on:12-01-2012

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    Author:

    Shanmugam S, Kamaraj K* and  Vetrichelvan T

    Title:Formulation and evaluation of lamivudine sustained release matrix tablets using synthetic polymers
    Journal:Journal of Pharmacy Research
    Vol(issue):5 (February)
    Year:2012
    Page No: (1063-1066)
  • Experimental Methods Keywords

    Methodology:Formulation and evaluation
    Research Materials:Lamivudine

Keywords

Lamivudine Matrix tablets Hydroxypropylmethylcellulose Ethyl cellulose Methyl cellulose.

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