Journal: Journal of Pharmacy Research

Article Id: JPRS-BMB-00001482
Title: In vitro prevention of oxidative damage by Curcuma amada in goat liver slices exposed to oxidative stress
Category: Biochemistry and Molecular Biology
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    Liver, the largest organ in vertebrate body, has a pivotal role in regulation of physiological processes. It is involved in several vital functions such as metabolism, secretion and storage. Furthermore, detoxification of a variety of drugs and xenobiotics occurs in liver. Most of the hepatotoxic chemicals damage liver cells mainly by inducing lipid peroxidation and other oxidative damages in liver. Even common dietary antioxidants can provide such protection from liver damage caused by oxidative mechanisms of toxic chemicals. A phytotherapeutic approach to modern drug development can provide many invaluable drugs from traditional medicinal plants. Search for pure phytochemicals as drugs is time consuming and expensive. In the present study one such medicinal plant Curcuma amada has been tested for their antioxidant activity in precision cut goat liver slices exposed to oxidative stress by hydrogen peroxide treatment. The activity of enzymic antioxidants and the levels of non enzymic antioxidants which decreased initially by H2O2 treatment was found to be increased on treatment with methanolic extract of both the leaves and rhizomes of Curcuma amada.

  • Abstract Audio

    No Audio file found

  • About the authors and Affiliations

    Author(s) Name:

    Sivaprabha, J., Dharani, B., Padma, P.R. and Sumathi,S*.

    Affiliation(s) Name:

    Department of Biochemistry, Biotechnology and Bioinformatics Avinashilingam Deemed University for Women, Coimbatore- 641 043,T.N., India

    *Corresponding author.
    Dr .S. Sumathi,
    Assistant Professor,
    Department of Biochemistry,
    Biotechnology and Bioinformatics,
    Avinashilingam Deemed University
    for Women,Coimbatore- 641 043
    Tamil Nadu, India

    Received on:10-11-2011; Revised on: 15-12-2011; Accepted on:12-01-2012

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    6 View More
  • How to Cite my Article.

    Author:

    Sivaprabha, J., Dharani, B., Padma, P.R. and Sumathi,S*.

    Title:In vitro prevention of oxidative damage by Curcuma amada in goat liver slices exposed to oxidative stress
    Journal:Journal of Pharmacy Research
    Vol(issue):5 (February)
    Year:2012
    Page No: (1108-1111)
  • Experimental Methods Keywords

    Methodology:antioxidants, phytochemicals, oxidative damage
    Research Materials:Curcuma amada

Keywords

Curcuma amada liver antioxidants phytochemicals hydrogen peroxide oxidative damage

Our Services

Most Downloaded List