Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-00001490
Title: Synthesis of some new 1,2,4-triazoles and 1,3,4-oxadiazoles as a safer anti-inflammatory and analgesic agents
Category: Pharmaceutical Chemistry
Section: Research Article
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  • Abstract

    A series of 1,2,4-triazole and 1,3,4-oxadiazole derivatives of phenoxyacetic acid were synthesized in order to obtain compounds with promising anti-inflammatory, analgesic activity and lower ulcerogenic potential. All compounds were evaluated for their anti-inflammatory activity by the carrageenan induced rat paw edema test method. The compounds possessing potent anti-inflammatory activity were further tested for their analgesic, ulcerogenic and lipid peroxidation activity. Out of all tested compounds, 3c and 5d showed anti-inflammatory and analgesic activity more than the standard drug ibuprofen. These compounds also showed reduced ulcerogenic potential and lipid peroxidation.

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    Author(s) Name:

    Md. Wasim Akhter,  Mohd. Amir*

    Affiliation(s) Name:

    Department of Pharmaceutical Chemistry, Hamdard University, New Delhi-110062, India

    *Corresponding author.
    Dr. Mohammad Amir
    Dept. of Pharmaceutical Chemistry
    Faculty of Pharmacy
    Hamdard University
    New Delhi- 110062,India.

    Received on:27-07-2014; Revised  on: 30-08-2014; Accepted on:11-09-2014

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    Md. Wasim Akhter,  Mohd. Amir*

    Title:Synthesis of some new 1,2,4-triazoles and 1,3,4-oxadiazoles as a safer anti-inflammatory and analgesic agents
    Journal:Journal of Pharmacy Research
    Vol(issue):9 (August)
    Page No: (1239-1247)
  • Experimental Methods Keywords

    Methodology: anti-inflammatory, analgesic, ulcerogenic, lipidperoxidation, hepatotoxic, histopathological
    Research Materials:Triazole, oxadiazole


Triazole oxadiazole anti-inflammatory analgesic ulcerogenic lipidperoxidation hepatotoxic histopathological

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