Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00001512
Title: Formulation and evaluation of fast dissolving tablets of Artemether and Lumefantrine
Category: Pharmaceutics
Section: Research Article
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    The present investigation is formulation and evaluation of fast dissolving tablets of artemether and lumefantrine. Artemether and lumefantrine are anitmalarial drugs used in the management of malaria. The objective of the proposed research work is to prepare and evaluate the fast dissolving tablets (FDTs) of artemether and lumefantrine, which avoid the first-pass metabolism, improved the dissolution rate and enhance the bioavailability. Fast dissolving tablets (FDTs) were prepared by direct compression method by using combination of superdisintegrant like, Crosspovidone and sodium starch glycolate(5%,10%,&15%) and evaluated for physico-chemical evaluation parameter such as hardness, friability, weight variation, drug content uniformity, water absorption ratio, wetting time, in-vitro and disintegration time, in-vitro dissolution studies. The control tablet (without superdisintegrant) was formulated and evaluated. The 12 formulations, F1to F6 were formulated and among these formulations, F3(crosspovidine) was optimized. The hardness, friability, weight variation and drug content were found to be within pharmacopeias limits. The water absorption ratio, wetting time, in-vitro  disintegration time of optimized formulation, F3 was found to be 62.87%, 12secs and 15secs  respectively. The formulation, F3 was considered to best formulation, which released up to 99.49% (artemether)&99.15%(lumefantrine)in 25 minutes. The comparison of dissolution rate profile of  formulation  and controlled formulation of artemether and lumefantrine tablet with best formulation, F3 was conducted. The result showed that the formulation, F3showed complete drug release within 25 minutes  and controlled formulation showed 26.50% (artemether) &24.50% (lumefantrine) drug release in 25 minutes. The stability study was also conducted the best formulation, F3 and it indicates that there was no significant change in any parameters. Hence the formulation F3 was considered to be highly stable.

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  • About the authors and Affiliations

    Author(s) Name:

    R. Margret Chandira*, P.Palanisamy, B.Jayakar, A.Pasupathi

    Affiliation(s) Name:

    Department of Pharmaceutics, Vinayaka Mission’s College of Pharmacy,Vinayaka Missions University,
     Yercaud Main Road, Kondappanaickenpatty, Salem (D.T) 636 008,Tamilnadu,India

    *Corresponding author.
    Dr. R.Margret Chandira,
                                     M. Pharmacy.,Ph.D.,
    Department of Pharmaceutics,
    Vinayaka Mission’s College of Pharmacy,
    Vinayaka Missions University,
    Yercaud Main Road, Kondappanaickenpatty,
    Salem (D.T) 636 008,Tamilnadu, India

    Received on:21-08-2014; Revised  on: 17-09-2014; Accepted on:22-10-2014

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    Author:

    R. Margret Chandira*, P.Palanisamy, B.Jayakar, A.Pasupathi

    Title:Formulation and evaluation of fast dissolving tablets of Artemether and Lumefantrine
    Journal:Journal of Pharmacy Research
    Vol(issue):8 (October)
    Year:2014
    Page No: (1467-1474)
  • Experimental Methods Keywords

    Methodology:Fast dissolving tablets, Water absorption ratio, Wetting time, In-vitro dissolution studies, Stability studies
    Research Materials:Artemether, Lumefantrine

Keywords

Artemether Lumefantrine Fast dissolving tablets Water absorption ratio Wetting time In-vitro dissolution studies Stability studies

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