Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001589
Title: Antihyperlipidemic effect of the aqueous extract from Cinnamomum tamala leaf in hyperlipidemic rats
Category: Pharmacology
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    Objective: The present work was undertaken to investigate the effects of aqueous extract from Cinnamomum tamala leaf in experimentally induced hyperlipidemia in rats. Materials and methods: The antihyperlipidemic effect of aqueous extract from Cinnamomum tamala leaf (CTLE) was evaluated in male albino rats of Wistar strain at two graded doses levels viz. 200 and 400 mg/kg of body weight. The following two models were used for the antihyperlipidemic activity, high fat diet and Triton X-100-induced hyperlipidemia in rat. CTLE (200 mg/kg, b.w. & 400 mg/kg, b.w.) was administered orally for 28 days in high fat diet and 7 days in Triton X-100 (100 mg/kg, i.p.) induced hyperlipidemia in rat. The efficacy of CTLE was compared to Standard Atorvastatin (30 mg/kg, p.o.) in high fat diet and Atorvastatin (10 mg/kg, p.o.) in Triton X-100-induced hyperlipidemia. Effect of CTLE on serum lipid profile like TC, TG, HDL-C, weight gain and LDL-C, and biochemical parameters like SGOT and SGPT were estimated. Result: CTLE significantly reduced the TC, TG, LDL-C and increase the HDL-C in both high fat diet & Triton X-100-induced hyperlipidemic rats. The increase in weight in rats administered with CTLE was less when compared to rats fed with high-fat diet and Triton X-100. The levels of SGOT and SGPT have been significantly (P < 0.001) decreased by the administration of CTLE in the experimental groups. The efficacy of CTLE was found to be comparing to Atorvastatin (30 mg/kg, p.o.) in high fat diet and Atorvastatin (10 mg/kg, p.o.) in Triton X-100-induced hyperlipidemia. CTLE showed a significant antihyperlipidemic effect in both high fat diet and Triton X-100-induced hyperlipidemic rats in a dose-dependent manner during 28 days and 7 days of treatment period. Conclusion: The results demonstrate that the CTLE has a definite antihyperlipidemic potential.

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  • About the authors and Affiliations

    Author(s) Name:

    Talha Jawaida, Sadiya Khatoona, Mehnaz Kamalb,*

    Affiliation(s) Name:

    aDepartment of Pharmacology, Hygia Institute of Pharmaceutical Education and Research,
    Ghaila Road, Lucknow, Uttar Pradesh - 226 020,  India
    bFaculty of Pharmacy, Integral University, Dasauli, Kursi Road, Lucknow, Uttar Pradesh - 226 026, India

    *Corresponding author.
    Dr. Mehnaz Kamal
    Assistant Professor,
    Faculty of Pharmacy, Integral University
    Dasauli, Kursi Road, Lucknow,
    Uttar Pradesh - 226 026, India

    Received on:17-06-2014; Revised  on: 30-07-2014; Accepted on:04-08-2014

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    Author:

    Talha Jawaida, Sadiya Khatoona, Mehnaz Kamalb,*

    Title:Antihyperlipidemic effect of the aqueous extract from Cinnamomum tamala leaf in hyperlipidemic rats
    Journal:Journal of Pharmacy Research
    Vol(issue):8(8)
    Year:2014
    Page No: (1098-1104)
  • Experimental Methods Keywords

    Methodology:Antihyperlipidemic activity
    Research Materials:Cinnamomum tamala

Keywords

Cinnamomum tamala; Antihyperlipidemic activity; High fat diet-induced; Triton X-100-induced; Atorvastatin.

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