Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00001594
Title: Formulation and evaluation of bioadhesive tablets of Metronidazole from Gellan gum and gelatin
Category: Pharmaceutics
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    Background: The delivery of drugs using a combination of bio-polymers is gaining extensive grounds in the development of newer drug delivery systems. In this work the formulation, evaluation and release profiles of metronidazole bioadhesive tablets formulated with admixtures of gellan gum and gelatin were investigated. Methods: Aqueous dispersions of gellan gum and gelatin in ratios of 1:1, 1:2, 2:1, 1:4, 1:0 and 0:1 were prepared in distilled water. Metronidazole tablets were prepared with the dispersions by wet granulation. The bioadhesive strengths of the dispersions and tablets were determined using the coated bead and tensiometric methods, respectively. Tablet parameters evaluated were weight uniformity, friability, hardness, disintegration time, content of active, swelling index and tablet erosion. Release studies were carried out in simulated intestinal and gastric fluid. Results: All batches of tablets met compendial specifications with regard to weight uniformity, friability, hardness and content of active except disintegration times. Tablets prepared with gelatin alone had the highest swelling index and bioadhesive strength (40 %, 5 h and 0.253 Nm-1) while those prepared with gellan gum alone had the highest percentage tablet erosion and least bioadhesive strength (15 % and 0.085 Nm-1). Release profiles of API from the tablets showed delayed effect with the highest % release in simulated intestinal fluid from tablets formulated with gum-gelatin ratio 1:1 (80 %, 80 min) followed by the gelatin alone batch (60 %, 80 min). Release kinetics and mechanism were first order and diffusion controlled. Conclusion: Gelatin increased the bioadhesive strength of gellan gum. Gellan gum-gelatin ratios of 1:2 and 1:4 were the optimum combinations and were superior in the formulation of metronidazole tablets. The hydrophilic bioadhesive polymers enhanced the steady release of the drug.

  • Abstract Audio

    No Audio file found

  • About the authors and Affiliations

    Author(s) Name:

    Sylvester Okhuelegbe Eraga* and Magnus Amara Iwuagwu

    Affiliation(s) Name:

    Department of Pharmaceutics and Pharmaceutical Technology,Faculty of Pharmacy, University of Benin, PMB 1154, Benin City, 300001, Nigeria.

    *Corresponding author.
    Sylvester Okhuelegbe Eraga
    Department of Pharmaceutics and Pharmaceutical Technology,
    Faculty of Pharmacy, University of Benin,
    PMB 1154, Benin City, 300001, Nigeria.

    Received on:30-06-2014; Revised  on: 19-07-2014; Accepted on:09-08-2014

     

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    Sylvester Okhuelegbe Eraga* and Magnus Amara Iwuagwu

    Title:Formulation and evaluation of bioadhesive tablets of Metronidazole from Gellan gum and gelatin
    Journal:Journal of Pharmacy Research
    Vol(issue):8 (August)
    Year:2014
    Page No: (1132-1139)
  • Experimental Methods Keywords

    Methodology:Formulation , evaluation, bioadhesive strengths,weight uniformity, friability, hardness, disintegration time, content of active, swelling index and tablet erosion etc
    Research Materials:Metronidazole

Keywords

Bioadhesion tablets gellan gum gelatin metronidazole

Our Services

Most Downloaded List