Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-00001600
Title: Inhibition Effect of Barley and Oat Aqueous Extract on the crystal growth rate of Calcium Oxalate Monohydrate Crystals
Category: Pharmaceutical Chemistry
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    The inhibiting effect of Barley (Ba) and Oat (Oa), aqueous extract on the precipitation rate of calcium oxalate crystals has been studied using constant composition technique in which the super-saturation and ionic strength were maintained constant at 37oC. The presence of aqueous extracts of Barley(Ba) and Oat (Oa),  even at relatively low concentration 10-6 M, markedly reduced the rates of precipitation. The suggestion of predominately surface Controlled mechanism is also supported by the observed low value of the activation energy Ea = 4.0 kcal/mol. The effective order of crystal growth reaction is determined in absence and presence of aqueous extract of additive where parabolic rate low with  n – 2 The action of additives can be interpreted in terms of adsorption, following the Langmuir isotherm, of additives at the active crystal growth sites. Dependence of the degree of inhibition with the change in driving force has been observed. The order of the degree of inhibition on the rate of crystal growth of calcium oxalate monohydrate for various additives studied is as follows Ba> Oa .These results suggest that the use of natural  plants ,weeds and its extracts  rather  than medicine prepared chemically which have vast side effects, may provide a useful drug manufacturing and therapeutic approach to urinary stones and many disease.           

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    Author(s) Name:

    Refaat A. Saber

    Affiliation(s) Name:

    Soil and Water Department, Faculty of Technology and Development, Zagazig University, Zagazig. Egypt .


    *Corresponding author.
    Refaat A. Saber       
    Soil and Water Department,
     Faculty of Technology and Development,
    Zagazig University, Zagazig. Egypt .

    Received on:15-06-2014; Revised  on: 22-07-2014; Accepted on:11-08-2014

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    Author:

    Refaat A. Saber

    Title:Inhibition Effect of Barley and Oat Aqueous Extract on the crystal growth rate of Calcium Oxalate Monohydrate Crystals
    Journal:Journal of Pharmacy Research
    Vol(issue):8(8)
    Year:2014
    Page No: (1162-1170)
  • Experimental Methods Keywords

    Methodology: Constant composition method, Seed crystals, Growth from solution, calcium oxalate monohydrate(COM).
    Research Materials:Crystal growth

Keywords

Crystal growth Constant composition method Seed crystals Growth from solution calcium oxalate monohydrate(COM).

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