Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-00001601
Title: Synthesis, anti-inflammatory and antioxidant activities of some new pyrazole derivatives
Category: Pharmaceutical Chemistry
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    Background: Pyrazole is an important class of heterocyclic compound, has been shown to exhibit diverse biological and pharmacological activities such as anti-cancer, antioxidant, anti-inflammatory, antimicrobial, etc. Methods: In this study, a series of novel pyrazole derivatives bearing hydrazone moiety have been synthesized via the reaction of the pyrazole carbohydrazide with different aldehydes. The structures of all compounds were confirmed via a wide range of spectroscopic techniques including IR, 1H NMR, and mass spectra. All synthesized compounds have been tested for their in vitro antioxidant activities using 1,1-biphenyl-2-picrylhydrazyl (DPPH) as a free radical scavenging reagent, and in vivo anti-inflammatory activities utilizing a standard acute carrageenan-induced paw edema. Results: The data reported herein indicates that compound 5a, 5c and 9 has emerged as potentially active compounds as anti-inflammatory and antioxidant compounds. Conclusions: All synthesized compounds were found to possess antioxidant & anti-inflammatory activities and could be useful as a template for future development through modification or derivatization to design more potent biologically active compounds.

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    Author(s) Name:

    Khalid Karrouchi1,3*, Laila Chemlal2, Latifa Doudach2, Jamal Taoufik1,
    Yahia Cherrah2, Smaail Radi3, My El Abbes Faouzi2 and M’hammed Ansar1

    Affiliation(s) Name:

    1Laboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, University Mohammed V Souissi, Rabat, Morocco.
    2Laboratory of Pharmacology and Toxicology, Pharmacokinetic Research Team,
    Faculty of Medicine and Pharmacy, University Mohammed V Souissi, Rabat, Morocco.
    3LCAE, Department of Chemistry, Faculty of Sciences, University Mohamed I, Oujda, Morocco.

    *Corresponding author.
    Dr. Khalid Karrouchi,
    University Mohammed-V Souissi,
    Faculty of Medicine and Pharmacy,
    Laboratory of Medicinal Chemistry,
    Rabat, Morocco

    Received on:21-06-2014; Revised  on: 18-07-2014; Accepted on:17-08-2014

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    Author:

    Khalid Karrouchi1,3*, Laila Chemlal2, Latifa Doudach2, Jamal Taoufik1,
    Yahia Cherrah2, Smaail Radi3, My El Abbes Faouzi2 and M’hammed Ansar1

    Title:Synthesis, anti-inflammatory and antioxidant activities of some new pyrazole derivatives
    Journal:Journal of Pharmacy Research
    Vol(issue):8(8)
    Year:2014
    Page No: (1171-1177)
  • Experimental Methods Keywords

    Methodology:anti-inflammatory activity, Antioxidant activity, DPPH, Carrageenan.
    Research Materials:Pyrazole

Keywords

Pyrazole anti-inflammatory activity Antioxidant activity DPPH Carrageenan.

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