Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001607
Title: Protective Effect of Curcumin in behavioral impairment induced by Pentylenetetrazol in rats
Category: Pharmacology
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    Hyperexcitability of brain neurons due to repetitive firing may initiate a complex pattern of neurophysiologiocal changes associated with cognitive impairment in epilepsy. In the present study, we evaluated the effect of curcumin in cognitive impairment and behavioral manifestations induced by Pentylenetetrazol (PTZ) in rats. PTZ was repeatedly injected on alternate days in a subconvulsive dose of 40mg/kg i.p of rats for a period of 30 days. We used Piperine orally as an bioavailability enhancer of curcumin. Carbamazepine (CBZ), a promising anticonvulsant was also used in the study to compare the anticonvulsant efficacy of curcumin.The seizure responses and mortality rate were observed in rats and behavioral activities were analyzed using active avoidance, passive avoidance and behavior despair test after administration of PTZ during the treatment period. The chronic administration of PTZ caused alterations in brain functions characterized by seizures and behavioral impairments. Curcumin treatment reduced the seizures, mortality rate and improved the learning and memory in a significant manner. The treatment with antiepileptic drug CBZ showed a marked reduction in seizure activity, mortality rate and memory impairment. A combined treatment of CBZ and curcumin significantly reduced the seizure scoring at all intervals and was found to revert the behavioral manifestations induced by PTZ. The present study clearly indicates that curcumin not only modulates the seizures but also improves the memory and learning ability by exerting its neuroprotective effect against PTZ induced kindling in rats.

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    Author(s) Name:

    Vandana Sharma1, Bimla Nehru2, Anjana Munshi1*, Sanjeev Sharma3, Pooja Khanna2

    Affiliation(s) Name:

    Institute of Genetics and Hospital for Genetic diseases, O.U, Hyderabad-16, India,
    Department of Biophysics, Panjab University, Chandigarh- 160014, India
    Apollo Hospital, Hyderabad-33, India
    *Corresponding author.
    Dr.Anjana Munshi,
    Scientist and Head
    Department of Molecular Biology,                
    Institute Of Genetics and Hospital for Genetic Diseases,Begumpet,                                   
    Hyderabad-500016, India    

    Received on: 15-09-2010; Revised  on: 18-11-2010; Accepted on:13-12-2010

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    Author:

    Vandana Sharma1, Bimla Nehru2, Anjana Munshi1*, Sanjeev Sharma3, Pooja Khanna2

    Title:Protective Effect of Curcumin in behavioral impairment induced by Pentylenetetrazol in rats
    Journal:Journal of Pharmacy Research
    Vol(issue):4 (January)
    Year:2011
    Page No: (11-14)
  • Experimental Methods Keywords

    Methodology:anticonvulsant activity
    Research Materials:Curcumin

Keywords

Curcumin Epilepsy Kindling Behavioral manifestations Carbamazepine Pentylenetetrazol.

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