Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-00001609
Title: synthesis and characterization of novel Pulegone derivatives as substitutes of 4-(1,1 dimethylethyl) cyclohexan-1-ol acetate
Category: Pharmaceutical Chemistry
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  • Abstract

    A series of novel pulegone derivatives were synthesized employing 1,4-addition of Gringard reagent followed by sodium borohydride reduction and esterification with optimum yields. The structures of synthesized esters were characterized by means of GC-MS, 1H and 13C NMR. The synthesized compounds GRP1, GRP2, GRP3 and GRP4 possesses woody fruity smell which can be used as good substitute of 4-(1, 1-dimethylethyl) cyclohexan-1-ol acetate.

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    Author(s) Name:

    Ashwani Kumar Dhingra1*, Bhawna Chopra1, Sakshi Bhardwaj1, K.L. Dhar2

    Affiliation(s) Name:

    1*Guru Gobind Singh College of Pharmacy, Yamunanagar, Haryana, India, 2Indosoviet Friendship College of Pharmacy, Moga, Punjab, India

    *Corresponding author.
    Ashwani Kumar Dhingra
    Guru Gobind Singh College of Pharmacy,
     Yamuna Nagar-135001,Haryana.

    Received on: 15-09-2010; Revised  on: 18-10-2010; Accepted on:13-12-2010

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    Author:

    Ashwani Kumar Dhingra1*, Bhawna Chopra1, Sakshi Bhardwaj1, K.L. Dhar2

    Title:synthesis and characterization of novel Pulegone derivatives as substitutes of 4-(1,1 dimethylethyl) cyclohexan-1-ol acetate
    Journal:Journal of Pharmacy Research
    Vol(issue):4 (January)
    Year:2011
    Page No: (19-21)
  • Experimental Methods Keywords

    Methodology:synthesis and characterization
    Research Materials: Pulegone

Keywords

Pulegone Chiral Pool Grignard reaction Essential oils ketone

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