Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001610
Title: Hemorrhagic colitis and its public health implications: A review
Category: Pharmacology
Section: Review Article
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    Hemorrhagic colitis also known as Hamburger’s disease is a type of food poisoning caused by a specific strain of Escherichia coli: E. coli 0157:H7. The causative agent produces toxins known as shiga-like toxins and also produces lesions causing hemorrhagic colitis with severe abdominal pains and cramps followed by bloody diarrhea. This strain of Escherichia coli infects the large intestine and produces toxins which kill the vascular endothelial cells with consequent epithelial necrosis. The disease is generally associated with ingestion of enterohemorrhagic E.coli (EHEC) in undercooked ground beef, unpasteurized fruit juices and milk. The pathogen is spread by the feacal-oral route, and an infectious dose appears to be only 500bacteria.Hemorrhagic colitis which is one of the worldwide diarrheal diseases is often misdiagnosed and causes 70,000 deaths annually. Several chemicals, toxins, drugs and infections can also cause hemorrhagic colitis. Oral administration of antibiotics, oseltamivir, sennoside- a laxative used for cleansing and treatment of constipation has been associated with hemorrhagic colitis. This tends to lead to certain complications such as high blood pressure. Early laboratory diagnosis (using Sorbitol MacConkey agar and other serological diagnosis) and a high sense of hygiene must be monitored carefully in slaughterhouses where contact of meat with faecal material can occur, and at homes where contaminated hands and utensils can aid the spread of the disease. 

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    Author(s) Name:

    Azuonwu.O, Abbey.S.D, Wokem.G.N, Adegoke

    Affiliation(s) Name:

    1Department of Medical Laboratory Sciences,Rivers State University of Science and Technology,P.M.B. 5080, Port Harcourt, Nigeria.

    *Corresponding author.
    Azuonwu, Obioma.
    Department of Medical Laboratory Science,
    Rivers State University of Science and Technology,
    Nkpolu, P.M.B 5080, Port Harcourt, Rivers State, Nigeria.

    Received on: 15-09-2010; Revised  on: 18-10-2010; Accepted on:13-12-2010

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    Azuonwu.O, Abbey.S.D, Wokem.G.N, Adegoke

    Title:Hemorrhagic colitis and its public health implications: A review
    Journal:Journal of Pharmacy Research
    Vol(issue):4 (January)
    Page No: (22-23)
  • Experimental Methods Keywords

    Methodology:Public Health Implications
    Research Materials:Hemorrhagic colitis


Hemorrhagic colitis Public Health Implications E. coli 0157:H7

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