Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00001613
Title: Natural Mucoadhesive Material Based Buccal Tablets of Nitrendipine-Formulation and In-vitro Evaluation
Category: Pharmaceutics
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  • Abstract

    In present investigation an attempt was made to formulate and evaluate oral buccoadhesive tablets of Nitrendipine using some natural mucoadhesive material like Zizyphus maurtiana(Jujube), Tamarind seed polysaccharide(TSP),also synthetic polymers like sodium CMC and HPMCK15M was tried .Prepared buccal tablets were comparatively evaluated for their physicochemical parameters like weight variation, hardness, friability, drug content uniformity test. The surface pH,swelling index,bioadheive strength ,in-vitro residence time ,ex-vivo permeation test also carried out which has been important  aspect for success of mucoadhesive buccal tablets all these parameters were evaluated shows comparatively better results in formulation containing natural mucoadhesive material than synthetic polymers. In vitro drug release rate of Nitrendipine prepared from this material was studied in isotonic phosphate buffers solution of pH 6.6 at 37 ± 0.50c from this it was found that mucoadhesive buccal tablets prepared from natural mucoadhesive material exhibited extended drug (85%) release up to 10 hrs compared to tablets prepared from synthetic material like sodium CMC and HPMCK15M.Drug release from tablets followed non-fickian diffusion controlled and zero order kinetics pattern up to 10 hrs.

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    Author(s) Name:

    Bangale G.S*1, Shinde G.V.1 Umalkar D.G.1, Rajesh K.S.2

    Affiliation(s) Name:

    1. Dept.of Pharmaceutics, Parul institute of Pharmacy, Vadodara, Gujarat.
    2. Indo Soviet Friendship College of Pharmacy, Ghalkalan Moga, Punjab.

    *Corresponding author.
    Bangale G.S
    Dept.of Pharmaceutics,
    Parul institute of Pharmacy, Vadodara, Gujarat,India

    Received on: 15-09-2010; Revised  on: 14-10-2010; Accepted on:13-12-2010

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    Author:

    Bangale G.S*1, Shinde G.V.1 Umalkar D.G.1, Rajesh K.S.2

    Title:Natural Mucoadhesive Material Based Buccal Tablets of Nitrendipine-Formulation and In-vitro Evaluation
    Journal:Journal of Pharmacy Research
    Vol(issue):4(1)
    Year:2011
    Page No: (33-38)
  • Experimental Methods Keywords

    Methodology:urface pH,swelling index,bioadheive strength ,in-vitro residence time ,ex-vivo permeation test
    Research Materials: Zizyphus maurtiana(Jujube)

Keywords

Buccal tablet Zizyphus maurtiana(Jujube) Tamarind seed polysaccharide (TSP) Swelling index Nitrendipine.

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