Journal: Journal of Pharmacy Research

Article Id: JPRS-PA-00001617
Title: Spectrophotometric Determination of Mesalamine by Pdac and Nqs Reagents in Bulk and Tablet Dosage Form
Category: Pharmaceutical Analysis
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    Two simple and sensitive visible spectrophotometric methods for the assay of mesalamine in bulk and pharmaceutical formulations have been carried out. Method A (λmax, 475nm) is based on the reaction of mesalamine with 1,2-naphthoquinone-4-sulphonate (NQS) in the presence of sodium hydroxide. Method B (lmax, 524nm) based on a condensation reaction between mesalamine and acidic solution of p-dimethyl amino cinnamaldehyde (PDAC) to form instant reddish brown colored product. All variables have been optimized and the reaction mechanisms are presented. Regression analysis of the Beer’s plots showed good correlation in the concentration ranges 1.0-16.0 mg/ m3 and 5.0-25.0 mg/m3 for methods A and B respectively. Recovery studies for mesalamine were found to be 96.6% and 98.0%. The %RSD values were found to be 0.447% and 0.395% when reacted with NQS and PDAC respectively. No interference is observed from excipients and the proposed method was statistically validated.

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    Author(s) Name:

    Navya Sloka Sama,  B.M. Gurupadayya*, and Ch. Aswani Kumar

    Affiliation(s) Name:

    Department of Pharmaceutical Analysis, JSS College of Pharmacy, JSS University, Mysore – 570 015, Karnataka, India

    *Corresponding author.
    Dr. B.M. Gurupadayya
    Department of Pharmaceutical Analysis
    JSS College of Pharmacy, JSS University, Mysore,
    S.S. Nagar, Mysore-570 015,Karnataka, India

    Received on: 15-09-2010; Revised  on: 14-10-2010; Accepted on:12-12-2010

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    Author:

    Navya Sloka Sama,  B.M. Gurupadayya*, and Ch. Aswani Kumar

    Title:Spectrophotometric Determination of Mesalamine by Pdac and Nqs Reagents in Bulk and Tablet Dosage Form
    Journal:Journal of Pharmacy Research
    Vol(issue):4 (January)
    Year:2011
    Page No: (39-41)
  • Experimental Methods Keywords

    Methodology:Spectrophotometric method
    Research Materials:Mesalamine

Keywords

Mesalamine Spectrophotometric method Para dimethyl amino cinnamaldehyde (PDAC) 1 2-Naphthoquinone-4-sulphonate (NQS)

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