Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-00001621
Title: Design, Synthesis, Spectral Characterization and Biological Evaluation of Mononuclear Ruthenium(II) Complexes
Category: Pharmaceutical Chemistry
Section: Research Article
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    Background: Two new mixed ligand ruthenium(II) complexes of the type [Ru(bpy)2(L)](PF6)2, where 2-[ 4,5-bis(4-dimethylaminophenyl)-1H- imidazol -2-yl]-1H-benzimidazole (1) and 2-[ 4,5-bis(4-fluorophenyl)-1H-imidazol-2-yl]-1H-benzimidazole (2) have been synthesized. Methods: Both the complexes were characterized by elemental analyses, UV-visible, IR and ESI-MS techniques. Cyclic and differential pulse voltammetry methods have been employed to study the redox behavior of complexes. Results and Discussion: Electrophoretic studies showed that the complexes are able to cleave supercoiled plasmid DNA more effectively in the presence of light at the wavelength of 480 nm. Moreover the newly synthesized complexes show better antimicrobial activity compared to that of the ligands. Cytotoxic activity against MCF7 cancer cell lines has been studied using MTT assay. Conclusion: Both the complexes exhibit significant biological activities against DNA, microbes and MCF7 cancer cell lines.  

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    Author(s) Name:

     Mathiyalagan Kiruthika1 and Periyasamy Dharmalingam2*

    Affiliation(s) Name:

    1Department of Chemistry, Arignar Anna Government Arts College, Musiri-621 211,Tamil Nadu, India
    2Department of Chemistry, Urumu Dhanalakshmi College, Tiruchirappalli, 620 019,Tamil Nadu, India.

    *Corresponding author.
    Dr.Periyasamy Dharmalingam
    Department of Chemistry,
    Urumu Dhanalakshmi College,
    Tiruchirappalli, 620 019,
    Tamil Nadu, India.

    Received on:23-07-2016; Revised  on:  14-08-2016; Accepted on: 07-09-2016   

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    Author:

     Mathiyalagan Kiruthika1 and Periyasamy Dharmalingam2*

    Title:Design, Synthesis, Spectral Characterization and Biological Evaluation of Mononuclear Ruthenium(II) Complexes
    Journal:Journal of Pharmacy Research
    Vol(issue):10 (October)
    Year:2016
    Page No: (623-628)
  • Experimental Methods Keywords

    Methodology:Design, Synthesis, Spectral Characterization, Biological Evaluation
    Research Materials:Benzimidazole

Keywords

Benzimidazole ruthenium(II) antimicrobial MCF7.

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