Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-00001627
Title: Cd (II) complex of some novel 5-nitroimidazole derivatives: Synthesis, characterization and antibacterial activity
Category: Pharmaceutical Chemistry
Section: Research Article
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    Background: Bacterial resistance development to the existing drugs has encouraged the search for novel targets. The novel metal complexes and their derivatives may represent an interesting approach for designing new antibacterial drugs. This may be due to the dual mechanism of both ligands and metal ion interacting in different stages of life cycle of bacteria.The aim of the present work was to synthesize a novel series of Cd (II) complexes of 2-(1-substituted-5-nitro-1H-imidazol-2-yl)-1-substitutedethanone and evaluate their in-vitro antibacterial activity. Methods: The metal-ligand complexes of cadmium have been synthesized in good yield. Synthesized complexes were evaluated in-vitro for their antibacterial activity by agar well diffusion method. Results: All the synthesized compounds were characterized by IR, 1H NMR, mass spectra and molar conductance. Some of the metal complexes were found to be moderately active against Gram-positive bacteria, B. pumilus ATCC 14884 and S. aureus ATCC 29737. Conclusion: Cd (II) complexes of 2-(1-substituted-5-nitro-1H-imidazol-2-yl)-1 substituted-ethanone have been synthesized and characterized. The synthesized complexes show inhibitory activity against only Gram-positive bacteria.

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    Author(s) Name:

    D. G. Desaia*, D. K. Surejaa, B. R. Prajapatib, A. K. Setha, K. I. Molvic

    Affiliation(s) Name:

    aDepartment of Pharmacy, Sumandeep Vidyapeeth, Po - Piparia, Ta - Waghodia, Vadodara - 391760, Gujarat, India
    bDepartment of Pharmaceutical Chemistry, L. M. College of Pharmacy, Navrangpura,Ahmedabad-380009, Gujarat, India
    c Ibn Sina National College for Medical Studies, Al-Mahjar, Jeddah - 22421, KSA

    *Corresponding author.
    Dr. D. G. Desai
    Department of Pharmacy,
    Sumandeep Vidyapeeth, Po - Piparia,
    Ta - Waghodia, Vadodara - 391760,
    Gujarat, India

    Received on: 09-09-2016; Revised on: 21-10-2016; Accepted on: 12-11-2016

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    Author:

    D. G. Desaia*, D. K. Surejaa, B. R. Prajapatib, A. K. Setha, K. I. Molvic

    Title:Cd (II) complex of some novel 5-nitroimidazole derivatives: Synthesis, characterization and antibacterial activity
    Journal:Journal of Pharmacy Research
    Vol(issue):10 (Nov)
    Year:2016
    Page No: (696-699)
  • Experimental Methods Keywords

    Methodology:Synthesis, characterization , Antibacterial activity.
    Research Materials:Cadmium (II) complex; 5-nitroimidazole

Keywords

Cadmium (II) complex; 5-nitroimidazole; Antibacterial activity.

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