Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001634
Title: Evaluation of the protective effects of Sapindus trifoliatus aqueous extract on vincristine induced neuropathic pain in rats
Category: Pharmacology
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    Aim: Evidences have been generated over past years that saponins possess anti-convulsant, neuroprotective, anti-neuralgic, anti-nociceptive, anti-migraine and anti-inflammatory effects. It has been documented that saponin is one of the major constituents in aqueous extract of Sapindus trifoliatus. Present study investigated the protective effects of Sapindus trifoliatus aqueous extract (AE-ST) on vincristine induced neuropathic pain in rats.  Materials and methods: Seven groups, each comprising of six SD rats, were employed in the present study. Painful neuropathy was induced in rats by administration of vincristine sulfate (75 µg/kg, i.p.) for 10 consecutive days. Spontaneous, mechanical, chemical and thermal nociceptive sensations were assessed at different time intervals i.e., 0, 3, 7, 9, 14 and 21. Biochemical alterations were determined on 21st day along with histopathological evaluations. Vincristine rats were co-administered aqueous extract of Sapindus trifoliatus (300, 100 and 30 mg/kg, p.o.) and pregabalin (10 mg/kg, p.o.) for 21 consecutive days. The data from the behavioral results were statistically analyzed by two-way ANOVA followed by Bonferonni’s post test. Data from the biochemical results were statistically analyzed by one-way ANOVA followed by Tukey’s multiple range test. Comparison results p < 0.05 were considered statistically significant.  Results: Administration of AE-ST significantly (p < 0.05) attenuated vincristine induced development of painful behavioral, biochemical and histological changes in a dose dependent manner similar to that of standard drug pregabalin as compared to vincristine control.  Conclusion: On the basis of data in hand, it may be concluded that AE-ST has potential ameliorating role in vincristine induced neuropathy which may be attributed to its multiple actions including anti-oxidative, anti-inflammatory and neuroprotective actions. 

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    Author(s) Name:

    Sachin Goyal*1, Gopal Menaria2, Dileep Kumar1, Himanshu Paliwal1, Shivali Singla1, Gurudas Khilnani3, Mukul Mathur4

    Affiliation(s) Name:

    1Department of Pharmacy, Mewar University, Gangrar, Chittorgarh, Rajasthan,India.
    2Pacific College of Pharmacy, Udaipur, Rajasthan,India.
    3RNT Medical College, Udaipur, Rajasthan,India.
    4SMS Medical College, Jaipur, Rajasthan,India.

    *Corresponding author.
    Dr. Sachin Goyal (M. Pharm, PhD, PDF)
    Department of Pharmacy
    NH – 79, Gangrar
    Chittorgarh – 312901
    Rajasthan (India)

    Received on:30-09-2016; Revised on: 27-10-2016; Accepted on: 31-10-2016

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    Author:

    Sachin Goyal*1, Gopal Menaria2, Dileep Kumar1, Himanshu Paliwal1, Shivali Singla1, Gurudas Khilnani3, Mukul Mathur4

    Title:Evaluation of the protective effects of Sapindus trifoliatus aqueous extract on vincristine induced neuropathic pain in rats
    Journal:Journal of Pharmacy Research
    Vol(issue):10(11)
    Year:2016
    Page No: (683-691)
  • Experimental Methods Keywords

    Methodology:Neuropathic pain, Vincristine, Oxidative stress, Neuroprotective
    Research Materials:Sapindus trifoliatus

Keywords

Sapindus trifoliatus Neuropathic pain Vincristine Oxidative stress Neuroprotective

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