Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-00001635
Title: Synthesis of 1-(5-Substituted Benzofuran-2-yl)-3-Arylurea Derivatives as Antimicrobial Agents
Category: Pharmaceutical Chemistry
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  • Abstract

    Background: Benzofurans are very interesting heterocycles, which are available in nature and show a wide range of pharmacological activities viz antifungal, antibacterial, antitumor, antimalarial, molluscicidal and antioxidant activity etc.  Methods: A convenient method for the preparation of 1-(5-substituted benzofuran-2-yl)-3-arylurea derivatives 6a-6r have been developed. The target compounds 1-(5-nitrobenzofuran-2-yl)-3arylurea 6a-6i and 1-(5-bromobenzofuran-2-yl)-3arylurea 6j-6r has been prepared by reacting 5-nitrobenzofuran-2-carbonyl azide 5a or 5-bromobenzofuran-2-carbonyl azide 5b with aromatic amines in reasonable overall yields. All the synthesized compounds were characterized using FT-IR, 1H NMR and mass spectrometry and were subjected to antimicrobial screening against two Gram positive bacteria (Staphylococcus aureus, Bacillus subtilis) two Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and two fungi (Candida albicans, Aspergillus niger) using two fold dilution method. Results and discussion: All the values of FTIR, 1H NMR and mass spectra were found to be prominent. The results indicate that synthesized compound 6d showed potent antimicrobial activity comparable to standard. Conclusion: The detailed synthesis, spectroscopic data and antimicrobial activities of synthesized compounds were reported. 

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    Author(s) Name:

    Shankar N. Budhwani1,*  Shailendra Sharma2,  Navanath V Kalyane3

    Affiliation(s) Name:

    1Faculty of Pharmaceutical Sciences, Jodhpur National University, Jodhpur, Rajasthan,India.
    2Jodhpur Institute of Pharmacy, Jodhpur National University, Jodhpur, Rajasthan,India.
    3B.L.D.E.A’S College of Pharmacy, Bijapur, Karnataka,India.

    *Corresponding author.
    Shankar N. Budhwani
    Faculty of Pharmaceutical Sciences,
    Jodhpur National University,
    Jodhpur, Rajasthan,India.

    Received on:18-09-2016; Revised on: 24-10-2016; Accepted on: 17-11-2016

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    Author:

    Shankar N. Budhwani1,*  Shailendra Sharma2,  Navanath V Kalyane3

    Title:Synthesis of 1-(5-Substituted Benzofuran-2-yl)-3-Arylurea Derivatives as Antimicrobial Agents
    Journal:Journal of Pharmacy Research
    Vol(issue):10 (Nov)
    Year:2016
    Page No: (703-708)
  • Experimental Methods Keywords

    Methodology:Antibactrial Activity, Antifungal Activity
    Research Materials:Benzofuran

Keywords

Benzofuran Antibactrial Activity Antifungal Activity

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