Journal: Journal of Pharmacy Research

Article Id: JPRS-ND-00001641
Title: Phytochemical and Biological Study of Some Constituents of Asparagus sprengeri Regel., Growing in Egypt
Category: Natural Drugs
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    Background: Asparagus sprengeri  Regel. is an ornamental small shrub native to coastal southeastern South Africa. The main objective of this study was the phytochemical and biological evaluation of ethanolic extract of non-flowering aerial parts of Asparagus sprengeri Regel., growing in Egypt. Methods: The investigation included analysis of the lipoidal compounds in the unsaponifiable and fatty acids fractions by GC/MS. Quantitative estimation of polyphenols, flavonoids and saponins by colourimetric methods. HPLC analysis of polyphenolic compounds was undergone, in addition to LC/MS of the saponins. Isolation of flavonoids was undergone using chromatographic methods and the identification was accomplished on the basis of their spectral data. Results: The unsaponifiable fraction was composed mainly of hydrocarbons (52.99%) and alcohols (31.54%). Moreover, the fatty acids fraction was composed of saturated (52.12%) and unsaturated (21.61%) ones. Determination of total polyphenols (9.83%) and flavonoids (1.87%) was undergone. HPLC analysis of polyphenols revealed that flavonoids were detected in higher amounts than phenolic acids. Extraction, isolation and identification of three flavonoids (kaempferol, quercetin and genistin) was achieved. Saponins (2.44%) were determined, while LC/MS of the n-butanol fraction indicated the presence of sprengerinin A,B,C&D. The ethanolic (70%) extract exhibited moderate antioxidant (IC50 = 56 µg ml-1) and potent cytotoxic activities. The most potent activity was that on colon cell line (IC50 = 3.73 µg ml-1), followed by the breast cell line (IC50 = 10.20 µg ml-1). Conclusion:  Thus, non-flowering aerial parts of Asparagus sprengeri Regel. could be considered as a potential source for different bioactive metabolites. 

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    Author(s) Name:

    Mona E.  El-Tantawy1, Omayma D. M. El-Gindi2, Ragia A. M. Taha3, Ghada F. Ibrahim1* and Doaa Y.  Elhadidy1

    Affiliation(s) Name:

    1Department of medicinal plants and natural products, National Organization for Drug Control and Research (NODCAR) , 2Egyptian Russian University, 3Faculty of Pharmacy for Girls, El-Azhar University.

    *Corresponding author.
    Ghada Farouk Metwally
    Lecturer of Pharmacognosy, Department of medicinal plants and natural products, National Organization for Drug Control & Research (NODCAR).
    Address: National Organization for Drug Control & Research (NODCAR), Wezaret El Zeraa st, 12611, Giza ,Egypt.

    Received on:25-09-2016; Revised  on:  28-10-2016; Accepted on: 06-12-2016    

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    Author:

    Mona E.  El-Tantawy1, Omayma D. M. El-Gindi2, Ragia A. M. Taha3, Ghada F. Ibrahim1* and Doaa Y.  Elhadidy1

    Title:Phytochemical and Biological Study of Some Constituents of Asparagus sprengeri Regel., Growing in Egypt
    Journal:Journal of Pharmacy Research
    Vol(issue):10 (Nov)
    Year:2016
    Page No: (802-809)
  • Experimental Methods Keywords

    Methodology:Phytochemical and Biological Study
    Research Materials:Asparagus sprengeri Regel

Keywords

Asparagus sprengeri Regel.; lipoidal matter; polyphenols; saponins; antioxidant; cytotoxic

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