Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001642
Title: A study on the Outcomes of Modified Tight Glucose Control for the Management of Glycemic Control in Diabetic Patients Undergoing Cardiac Surgery
Category: Pharmacology
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    Background and Objective: Diabetes mellitus is associated with increased surgical morbidity and mortality.Its relatively high risk may be related to the level of perioperative hyperglycemia. Thisstudy was aimed to compare the outcomes of patients undergoing open cardiac surgery byglucose control in two ways: modified tight versus conventional method. Methods: This open-labeled, randomized control trial was conducted on 75diabetic patients (18-70 years old) with ASA II- III undergoing open cardiac surgery from Shahid Faghihi Hospital, Shiraz, Iran. The patients were randomly divided into modified tight control(Blood Sugar maintained between 100-120 mg/dl) and conventional method (Blood Sugar < 200mg/dl). Primary end points included: hospitalmortality, sternal wound infection, duration of mechanical ventilation, cardiacarrhythmia, cerebrovascular attack and acute renal failure. The secondary end point waslength of ICU staying. Complications after 30 days of surgery were recorded. We used student’s t test, chi-squareand repeated measurement tests. Results: Although the trend of change in blood glucose during surgery and in ICU was notsignificantly different between groups, blood sugar measurement showed a significantdifference at the different times (P<0.001). In terms of primary end pointsandsecondary end pointwere not significantly different between two groups. The occurrence of hypoglycemiawas low in both groups (one patient in each group) and were not significantly different between two groups.Hypokalemia was the most prominent sideeffect in the 34 patients of modified tight control group compared with eight patients in theconventional group (P<0.001). After 30 days sternal wound infection was seen in1 patient oftreatment group versus 7 in control group (P<0.05), which was significant. Conclusion: Modified tight control of blood glucose close tonormal values during cardiac surgery was associated with decreased occurrence of episodes of hypoglycemia andhyperglycemic complications.

  • Abstract Audio

    Click Here

  • About the authors and Affiliations

    Author(s) Name:

    FatemehJavaherforooshZadeh1,2*, Mohammad Ghazi Nour3

    Affiliation(s) Name:

    1Associate professor of Anesthesia, Department of cardiac anesthesia,Ahvaz Anesthesiology and Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
    2Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
    3Assistant professor of cardiac surgery, Department of cardiac surgery, Shiraz University of Medical Sciences, Shiraz, Iran.

    *Corresponding author.
    FatemehJavaherforooshZadeh
    Associate professor of Anesthesia,
    Department of cardiac anesthesia,
    Ahvaz Anesthesiology and Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

    Received on:14-09-2016; Revised  on:  25-10-2016; Accepted on: 04-11-2016 

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    FatemehJavaherforooshZadeh1,2*, Mohammad Ghazi Nour3

    Title:A study on the Outcomes of Modified Tight Glucose Control for the Management of Glycemic Control in Diabetic Patients Undergoing Cardiac Surgery
    Journal:Journal of Pharmacy Research
    Vol(issue):10 (Nov)
    Year:2016
    Page No: (764-770)
  • Experimental Methods Keywords

    Methodology:Diabetes
    Research Materials:Glucose,

Keywords

Cardiac surgery Diabetes; outcome Glycemic control

Our Services

Most Downloaded List