Journal: Journal of Pharmacy Research

Article Id: JPRS-HM-00001644
Title: Antianxiety activity of Carissa congesta weight leaves
Category: Herbal medicine
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    The aim of the present study was to investigate the antianxiety activity of various extracts of Carissa congesta leaves. In the present investigation, leaves of the plant were extracted using solvents in order of increasing polarity viz., petroleum ether (60-800C), chloroform,ethyl acetate and ethanol. All the crude extracts were evaluated for anti-anxiety activity in mice using elevated plus maze apparatus. Among all these extracts, ethyl acetate and ethanolic extract exhibited significant anti-anxiety activity at a dose of 400 mg/kg in mice with respect to control as well as standard (diazepam, 4 mg/kg).It was observed that at the dose of 400 mg/kg dose the Ethyl acetate and Ethanolic extract shows increase the time spent and the number of arm entries in the open arms of the elevated plus-maze. As phytochemical screening of ethanolic extract showed presence of polyphenols, i.e., flavonoids and tannins, thus, these constituents might be responsible for anxiolytic potential of Carissa congesta.

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    Author(s) Name:

    Manisha Shinde1*, Sanjay Chaudhari2, Bharati Zaware1

    Affiliation(s) Name:

    1Gyan vihar University,Jaipur ,Rajasthan,India
    2Amrutvahini College of Pharmacy, Sangamner, Maharashtra, India

    *Corresponding author.
    Manisha Shinde
    Gyan vihar University,
    Jaipur ,Rajasthan,India

    Received on:26-10-2016; Revised on: 12-11-2016; Accepted on: 14-12-2016

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    Manisha Shinde1*, Sanjay Chaudhari2, Bharati Zaware1

    Title:Antianxiety activity of Carissa congesta weight leaves
    Journal:Journal of Pharmacy Research
    Page No: (825-828)
  • Experimental Methods Keywords

    Methodology: antianxiety, elevated plus maze.
    Research Materials:Carissa congesta


Carissa congesta antianxiety diazepam elevated plus maze.

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