Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-000017
Title: Effect of Different Viscosity Grades of HPMC on Drug Release Profile
Category: Pharmaceutics
Section: Research Article
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    In this study, different grades of hydroxyl propyl methyl cellulose (HPMC) were used to develop floating microspheres of Cefpodoxime Proxetil in order to demonstrate the effect of different viscosities on drug release profile. The Cefpodoxime Proxetil microspheres were prepared by non aqueous solvent evaporation method using different grades of HPMC such as HPMC K15M( 15cps), HPMCK4M(4000cps), HPMC100LV(100cps) and ethyl cellulose. The prepared microspheres were characterized by polymer compactibility (FTIR Scan), percentage yield, Buoyancy percentage, Drug Entrapment Efficiency (DEE) and invitro drug release was performed by USP Apparatus type I. The prepared floating microspheres were found to produce the percentage yield of 50.5-72.21%, Drug Entrapment Efficiency of 14.1-28.2%, Buoyancy percentage of 70.1-88.25% and drug release of microspheres of 65.09-101.88%. The better drug release profile was found to be with formulation (F A2 ) with drug:polymer ratio of 1:2, HPMC 15cps showed much significant increase in the drug release while comparing with the other two grades of HPMC.

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    Author(s) Name:

    Deepa Karthikeyan*1 , Karthikeyan .M 2 and Ramasamy .C 3

    Affiliation(s) Name:

    1Department of Pharmaceutics, JDT Islam College of Pharmacy, Marikkunnu, Jamiath hill, Malabar, Calicut – 673012, Kerala State,
    India.
    2Department of Pharmacology, Malik deenar college of pharmacy, seethangoli , bela post, kasaragod -671321, Kerala state , India
    3Department of Pharmaceutics, Aadhi Bhagawan College of Pharmacy, Rantham village, Cheyyar TK,Thiruvannamalai dist,Tamil  Nadu- 604 407,India.


    For correspondence:

    Deepa Karthikeyan.,

    Department of Pharmaceutics, JDT Islam College of Pharmacy,
    Marikkunnu, Jamiath hill, Malabar, Calicut – 673012, Kerala State, India.

    E-mail: deepa81mk@yahoo.co.in


    Received on: 10-05-2008; Accepted on :24-07-2008

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    Author:

    Deepa Karthikeyan*1 , Karthikeyan .M 2 and Ramasamy .C 3

    Title:Effect of Different Viscosity Grades of HPMC on Drug Release Profile
    Journal:Journal of Pharmacy Research
    Vol(issue):1 (July-September 2008)
    Year:2008
    Page No: (23-28)
  • Experimental Methods Keywords

    Methodology:Floating microspheres
    Research Materials:Cefpodoxime Proxetil

Keywords

Floating microspheres Cefpodoxime Proxetil HPMC K15 HPMC K4M HPMC K 100 in vitro release studies bioavailability.

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