Journal: Journal of Pharmacy Research

Article Id: JPRS-PB-00001704
Title: Optimization of physiochemical parameters for the production of withaferin A employing cell suspension culture of Withania somnifera : A review
Category: Pharmaceutical Biotechnology
Section: Review Article
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    Withania  somnifera  (Ashwagandha )  is  a  plant  used  in  medicine  from  the  time  of presence by ayurveda, the  ancient  system  of  Indian  medicine  and  in  plant  biotechnology. The  dried  roots  and  leaves   of  the  plant  are  used  in  the  treatment  of  various  nervous  and  sexual  disorders. Medicinal  properties  of  plant  have  been  attributed  to  the  presence of  a  group  of  steroidal  lactones  which  are  known  as   withanolides  which  are  present  in  roots  and leaves. Withaferin  A  is  a  steroidal  lactone  being   derived  from  Withania  somnifera. It  is  used  in  ayurvedic  medicine. It  has  a  wide  range  of  activities  which  comes  under  pharmacy ,cardio protection, the  anti-inflammatory  agent ,  an  immuno  modulatory,  an   anti-angiogenesis, anti-metastasis  and anti-carcinogenic  property.  This  review  article  is     focusing  on   the  methodology  to  achieve  the  maximum  production  of  withaferin  A  employing cell  suspension  culture  of  Withania  somnifera.  As  withaferin  A  low  concentration  was  found  to  be  a  limiting  factor  in  previous  reports   on  Withania  somnifera . This  article  will  encompass  the  parameters  which  are  responsible  for  optimum  production  of  withaferin  A   employing  cell  suspension  culture  of  Withania  somnifera.

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    Author(s) Name:

    Anchal  Verma ¹,², Seema  Ahlawat¹ , Abhimanyu  Kumar  Jha² , M.Z. Abdin ¹ 

    Affiliation(s) Name:

    ¹ Department of Biotechnology , Jamia Hamdard Deemed University , Hamdard Nagar,Delhi 110062 India
    ² Department of Biotechnology, IMS Engineering College, Ghaziabad, Uttar Pradesh 201009 India.

    *Corresponding author.
    Dr. M.Z. Abdin
    Head and Professor of Biotechnology,
    Centre for Transgenic Plant Development,
    Jamia Hamdard Deemed University.New Delhi

    Received on:12-09-2016; Revised on: 22-02-2017; Accepted on: 30-03-2017

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    Author:

    Anchal  Verma ¹,², Seema  Ahlawat¹ , Abhimanyu  Kumar  Jha² , M.Z. Abdin ¹ 

    Title:Optimization of physiochemical parameters for the production of withaferin A employing cell suspension culture of Withania somnifera : A review
    Journal:Journal of Pharmacy Research
    Vol(issue):11 (April)
    Year:2017
    Page No: (267-271)
  • Experimental Methods Keywords

    Methodology:,anti-inflammatory, cardioprotective,physiochemical parameters,cell suspension culture
    Research Materials:Withania somnifera

Keywords

Withaferin A anti-inflammatory withanolides cardioprotective.

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