Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001719
Title: Assessment of phytochemical & pharmacological activities of the ethanol leaves extracts of Myrica esculenta BUCH. HAM.
Category: Pharmacology
Section: Research Article
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    OBJECTIVE: To elucidate potential antioxidant, antidiarrheal, anthelmintic and antibacterial activity of ethanol leaves extract of Myrica esculenta Buch. Hum. in different experimental models established in vitro and in vivo. METHODS: In vitro antioxidant activity was evaluated by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging assay. In vivo antidiarrheal studies was carried out in mice, and the activity was evaluated in castor oil induced diarrhea, anthelmintic activity on Paramphistomum cervi and Haemonchus contortus, and Disk diffusion assay was utilized to determine antibacterial activity against a number of pathogenic bacterial strains. RESULTS: In DPPH radical-scavenging assay, the extract exhibited strong radical-scavenging activity with the 50% inhibitory concentration value of 48.28 ìg/ml. The extract significantly (p<0.001) enhanced the latent period and decreased the defecation in castor-oil induced diarrhea. The extract exhibited dose-dependent decrease in paralysis and death time of the helminthes. Potential antibacterial activity was exhibited by the extract against all the tested bacterial strains in disk diffusion assay. CONCLUSION: The result demonstrated that the ethanol leaves extract of M. esculenta has potential antioxidant, antidiarrheal, anthelmintic and antibacterial activity.

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    Author(s) Name:

    Bipin Kumar Nayak1*, Purabi Deka1, N. Eloziia1

    Affiliation(s) Name:

    1Division of Pharmaceutical Sciences, Shri Guru Ram Rai Institute of Technology & Science, Patel Nagar, Dehradun 248001, Uttarakhand, India.

    *Corresponding author
    Bipin Kumar Nayak
    Division of Pharmaceutical Sciences,
    Shri Guru Ram Rai Institute of Technology & Science,
    Patel Nagar, Dehradun 248001, Uttarakhand, India.

    Received on:11-04-2017; Revised on: 28-04-2017; Accepted on: 16-05-2017

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    Author:

    Bipin Kumar Nayak1*, Purabi Deka1, N. Eloziia1

    Title:Assessment of phytochemical & pharmacological activities of the ethanol leaves extracts of Myrica esculenta BUCH. HAM.
    Journal:Journal of Pharmacy Research
    Vol(issue):11 (May)
    Year:2017
    Page No: (444-449)
  • Experimental Methods Keywords

    Methodology: antioxidant activity, antidiarrheal activity, anthelmintic activity, antibacterial activity
    Research Materials:Myrica esculenta

Keywords

Myrica esculenta antioxidant activity antidiarrheal activity anthelmintic activity antibacterial activity mice.

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