Journal: Drug Invention Today

Article Id: JPRS-PS-00001727
Title: Hepatoprotective activity of Bridelia retusa leaves against paracetamol-induced liver damage in Swiss albino mice
Category: Pharmacological Screening
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    The present study is aimed to evaluating the hepatoprotective effect of Bridelia retusa leaves extracts by paracetamol-induced liver damage in swiss albino mice.The degree of protection was measured by using biochemical parameters such as serum glutamate oxalate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), bilirubin.. Treatment with Bridelia retusa leaves extracts showed significant reduction in level of SGOT, SGPT, ALP and total bilirubin almost comparable to the Silymarin. The hepatoprotection confirmed by histopathological examination of the liver tissue. From the result it can be concluded that Bridelia retusa leaves possesses hepatoprotective effect against paracetamol –induced liver damage in mice.

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    Author(s) Name:

    Ghawate V. B.* 1,2, Purnima Shrivastava1, Bhambar R. S3

    Affiliation(s) Name:

    1Department of Pharmaceutical Sciences, Bhagwant University, Ajmer, Rajasthan.India.1Department of Pharmaceutical Sciences, Bhagwant University, Ajmer, Rajasthan.India.

    2Department of Pharmacognosy, MES College of Pharmacy, Sonai, Ahmednagar, Maharashtra,India.

    3MGV’s College of Pharmacy, Panchwati, Nasik, Maharashtra,India. 

    *Corresponding author
    Ghawate V. B.
    Department of Pharmacognosy,
    MES College of Pharmacy, Sonai,
    Ahmednagar, Maharashtra,India.

    Received on:22-01-2017;Revised on: 26-02-2017; Accepted on: 30-03-2017

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    Author:

    Ghawate V. B.* 1,2, Purnima Shrivastava1, Bhambar R. S3

    Title:Hepatoprotective activity of Bridelia retusa leaves against paracetamol-induced liver damage in Swiss albino mice
    Journal:Drug Invention Today
    Vol(issue):9 (May)
    Year:2017
    Page No: (9-12)
  • Experimental Methods Keywords

    Methodology:Hepatoprotective activity
    Research Materials:Bridelia retusa

Keywords

Bridelia retusa Hepatoprotection Paracetamol Silymarin.

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