Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-00001801
Title: Characterization and formulation of prednisolone acetate reconstituted suspension
Category: Pharmaceutics
Section: Research Article
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    Objective: An oral suspension is commonly applicable to a drug which poorly soluble or unstable in solutions. Prednisolone acetate is a poor water-soluble corticosteroid used for the treatment of many inflammations. Therefore it was formulated as a reconstituted oral suspension. Methods: Various types and concentrations of the suspending agents, including: xanthan gum, avicel , hydroxyl propyl methylcellulose (HPMC), and sodium carboxymethylcellulose (SCMC) were used in the formulation either alone or in combination. In powder form, flowability tests which include an angle of repose, Carr’s index, and Hausner’s ratio were evaluated. After constitution PH, rheology, sedimentation , resuspendability, palatability and dissolution were investigated in liquid suspension. Results: The results showed that all formulas showed acceptable flowability when evaluated as the powder before the constitution. Rapid sedimentation of constituents was occurred in formulas containing avicel. Formulas contain xanthan gum (0.5%) or HPMC (5%) alone or in combination (xanthan gum 0.25% + HPMC 2%) showed the desired PH, palatability, sedimentation, resuspendability,rheology and dissolution in comparison with formulas contain avicel, SCMC, xanthan gum (0.25%), HPMC (2%) or formula of a combination of (xanthan 0.5% + HPMC 5%) and xanthan gum with SCMC at various concentrations used. Conclusion: The formulas which contains xanthan gum 0.5% and HPMC 2% or combination (xanthan gum 0.25% + HPMC 2%) were the best based on the sedimentation,rheology ,dissolution and stability.

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  • About the authors and Affiliations

    Author(s) Name:

    1Ali Sattar Kurji, *2Fatima Al Gawhari

    Affiliation(s) Name:

    1Department of general health -Diyala health office , Diyala,Iraq
    2 Department of pharmaceutics -University of Baghdad, Baghdad, Iraq

    *Corresponding author
    Dr. Fatima Al . Gawhari
    Department of pharmaceutics,
    University of Baghdad ,
    Baghdad, Iraq

    Received on:10-04-2017; Revised on: 17-05-2017; Accepted on: 30-06-2017

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    Author:

    1Ali Sattar Kurji, *2Fatima Al Gawhari

    Title:Characterization and formulation of prednisolone acetate reconstituted suspension
    Journal:Journal of Pharmacy Research
    Vol(issue):11 (July)
    Year:2017
    Page No: (815-822)
  • Experimental Methods Keywords

    Methodology:Characterization and formulation
    Research Materials:prednisolone acetate

Keywords

Reconstituted prednisolone acetate powder.

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