Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-00001802
Title: Synthesis, characterization, and biological evaluation of some novel 1,3,4-oxadiazoles for their antimicrobial and anti-inflammatory activities
Category: Pharmaceutical Chemistry
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  • Abstract

    Heterocyclic compounds have occupied a prominent place among various classes of organic compounds by virtue of their diverse biological activities and chemistry. Oxadiazoles are important pharmacophores in modern drug discovery. Among oxadiazoles, 1,3,4-oxadiazoles skeleton occupies a significant place in numerous bioactive molecules with a wide range of activities such as antimicrobial, anticancer, analgesic, anti-inflammatory, and anticonvulsant. The aim is to synthesize a drug with better efficacy, less toxicity, and fewer side effects. In view of the important biological activities in the present work, an attempt has been made to synthesize some novel oxadiazole derivatives and evaluate the biological profile of these compounds. The proposed molecules have been synthesized by reacting methyl salicylate and hydrazine hydrate which further reaction in the presence of carbon disulfide and potassium hydroxide yields 5-(2-hydroxyphenyl)-2-mercapto-1,3,4-oxadiazole derivatives of oxadiazoles were successfully obtained by condensation of mercapto oxadiazoles with different substituted aromatic carboxylic acids. The purity of the compounds was ascertained by melting point and thin-layer chromatography. The structures of the synthesized compounds have been characterized by the extensive use of Fourier transform infrared, H nuclear magnetic resonance, and mass spectral analysis. The title compounds were evaluated for antimicrobial and anti-inflammatory activities by the cup-plate method and carrageenan-induced rat paw edema method. All the test compounds exhibited pronounced antimicrobial and anti-inflammatory activity against the standards.

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    Author(s) Name:

    Deepa Mopuri1*, N. Pramod1, A. Madhu Latha1, V. Sarovar Reddy2

    Affiliation(s) Name:

    1Department of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, Rajampet - 516 126, Andhra Pradesh, India,
    2Department of Pharmaceutics, Annamacharya College of Pharmacy, Rajampet - 516 126, Andhra Pradesh, India

    *Corresponding author: Deepa Mopuri, Department of Pharmaceutical Chemistry, Annamacharya College of Pharmacy, Rajampet - 516 126, Andhra Pradesh, India.

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    Author:

    Deepa Mopuri1*, N. Pramod1, A. Madhu Latha1, V. Sarovar Reddy2

    Title:Synthesis, characterization, and biological evaluation of some novel 1,3,4-oxadiazoles for their antimicrobial and anti-inflammatory activities
    Journal:Journal of Pharmacy Research
    Vol(issue):11(8)
    Year:2017
    Page No: (916-920)
  • Experimental Methods Keywords

    Methodology:Anti-inflammatory, Antimicrobial, H nuclear magnetic resonance, Thin-layer chromatography
    Research Materials:1,3,4-oxadiazole

Keywords

1 3 4-oxadiazole Anti-inflammatory Antimicrobial H nuclear magnetic resonance Thin-layer chromatography

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