Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001816
Title: Evaluation of hepatoprotective activity of the hydroalcoholic extract of leaves of Urtica dioica
Category: Pharmacology
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    Objectives: Urtica dioica has been reported to have an antioxidant activity, so it may be used for the prevention of hepatotoxicity which is caused by oxidative stress with excessive formation of reactive oxygen species and peroxynitrite. The current study investigates the hepatoprotective activity of the hydroalcoholic extract of leaves of U. dioica. Materials and Methods: Atotal of 36 rats were divided into six groups. Group 1 served as a control, Groups 2 and 3 served as negative control and standard, while Groups 4-6 were administered with 100, 200, and 400 (mg/kg b.w.) doses of plant extract, respectively. On the 7th day after 2 h of respective treatments, the blood samples were collected for the estimation of biochemical marker enzymes (serum glutamic oxaloacetic transaminase [SGOT], serum glutamate-pyruvate transaminase [SGPT], and alkaline phosphatase [ALP]) as well as total bilirubin, and total cholesterol. Then, animals were sacrificed for histopathological examination. Results: Treatment with paracetamol significantly increased the serum SGPT, SGOT, ALP, bilirubin, and cholesterol. Treatment with silymarin and 100, 200, and 400 mg/kg of a hydroalcoholic extract of U. dioica leaves has significantly brought down the levels of SGPT, SGOT, ALP, bilirubin, and cholesterol. The extract of U. dioica exhibited a concentration-dependent antiradical activity by quenching 2,2-diphenyl-1-picrylhydrazyl radical and scavenging nitric oxide radical. U. dioica extract has also shown the ability to reduce oxidative stress by increasing the glutathione level and preventing lipid peroxidation. Conclusion: U. dioica has potent hepatoprotective action on paracetamol induced hepatic damage in rats.

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    Author(s) Name:

    Gurkiran Kaur1, Navneet Duggal1*, Gopal L. Khatik2

    Affiliation(s) Name:


    1Department of Pharmacology, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India,
    2Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara,Punjab, India


    *Corresponding author: Navneet Duggal, Department of Pharmacology, School of Pharmaceutical Sciences, LovelyProfessional University, Phagwara, Punjab, India.

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    Author:

    Gurkiran Kaur1, Navneet Duggal1*, Gopal L. Khatik2

    Title:Evaluation of hepatoprotective activity of the hydroalcoholic extract of leaves of Urtica dioica
    Journal:Journal of Pharmacy Research
    Vol(issue):11(9)
    Year:2017
    Page No: (1063-1066)
  • Experimental Methods Keywords

    Methodology: Hepatoprotective, Hepatotoxicity
    Research Materials:Urtica dioica

Keywords

Hepatoprotective Hepatotoxicity Paracetamol Silymarin Urtica dioica

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