Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001820
Title: Neuroprotective role of Pterocarpus marsupium Roxb in streptozotocin-induced diabetic neuropathic pain in Type 2 diabetic rats
Category: Pharmacology
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    Aim: The present study was aimed to evaluate the neuroprotective effects of aqueous extract of Pterocarpus marsupium Roxb (PM) on the pain threshold response in streptozotocin (STZ)-induced diabetic neuropathic pain. Material and Methods: STZ (40 mg/kg; i.p.) administered for 4 weeks in rats was monitored in 0th and 8th week by measuring blood sugar levels and body weight. Thermal hyperalgesia, mechanical hyperalgesia, and thermal allodynia were performed in 0th, 4th, 6th, and 8th week of the study. At the end of 8th week study, formalin-evoked pain model followed by measurement of tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β and IL-6 level, and morphological changes in sciatic nerve were studied. All the rats except the vehicle-treated group received insulin 1 IU/kg/day to maintain plasma glucose levels. Results and Discussions: After 4 weeks of diabetic induction, administration of PM (100 and 200 mg/kg) along with 1 IU/day for 4 weeks had no significant effect on body weight and feed intake when compared to control rats. Pregabalin (10 mg/kg) and PM (100 mg/kg and 200 mg/kg) were injected for 4 weeks significantly attenuated the nociception in behavioral models. Furthermore, pregabalin and PM significantly inhibited the TNF-α, IL-1β, and IL-6 levels comparable to STZ group. In comparison to STZ with insulintreated rats, PM exhibited significant increase in the pain threshold response. PM also reversed the STZ-induced axonal degeneration and deposition of collagen fibers in the sciatic nerve. Conclusion: The study concludes that neuroprotective effect of PM in STZ-induced neuropathic pain can be attributed to its anti-inflammatory and neuroregeneration mechanism.

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    Author(s) Name:

    Venkatesh Gunasekaran *, Merin Maria Mathew, Mrinmoy Gautam, M. Ramanathan

    Affiliation(s) Name:

    Department Of Pharmacology, PSG College of Pharmacy affiliate to Dr. M. G. R Medical University, Tamil Nadu, India.

    *Corresponding author: Venkatesh Gunasekaran, Department of Pharmacology,  PSG College of Pharmacy, Peelamedu,Coimbatore - 641 004, Tamil Nadu, India

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    Author:

    Venkatesh Gunasekaran *, Merin Maria Mathew, Mrinmoy Gautam, M. Ramanathan

    Title:Neuroprotective role of Pterocarpus marsupium Roxb in streptozotocin-induced diabetic neuropathic pain in Type 2 diabetic rats
    Journal:Journal of Pharmacy Research
    Vol(issue):11(9)
    Year:2017
    Page No: (1112-1121)
  • Experimental Methods Keywords

    Methodology: Histopathology, Inflammatory marker,Neuroprotective role
    Research Materials:Pterocarpus marsupium Roxb

Keywords

Histopathology Inflammatory marker Pterocarpus marsupium Roxb Sciatic nerve Streptozotocin

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