Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-00001821
Title: Synthesis and Antibacterial Activity of Novel 3-[5-(4-substituted) phenyl-1,3,4-oxadiazole-2yl]-2-styrylquinazolin-4(3H)-ones
Category: Pharmaceutical Chemistry
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    Purpose: Our previous studies (Gupta et al., 2007) have demonstrated the effectiveness of synthesized series of 3-[5-(4-substituted) phenyl-1,3,4-oxadiazole-2yl]-2-styrylquinazolin-4(3H)-one derivatives as antimicrobial agents. In this work, the effect of substitution of electron withdrawing groups at the phenyl-1,3,4-oxadiazole moiety was investigated. Approach: Nitro group (NO2 ) and fluorine group (F) were substituted each at the 4th position of phenyl-1,3,4-oxadiazole moiety to produce 3-(5-(4-nitrophenyl)- 1,3,4-oxadiazol-2-yl)-2-styrylquinazolin-4(3H)-one and 3-(5-(4-fluorophenyl)- 1,3,4-oxadiazol-2-yl)-2-styrylquinazolin- 4(3H)-one, respectively. Findings: Synthesized compounds were confirmed by infrared and nuclear magnetic resonance spectra. Their antimicrobial activity was tested against Gram-positive Bacillus subtilis and Gram-negative Escherichia coli using cup-plate method. The two synthesized compounds were found to possess substantial antibacterial activity. They exhibited higher antibacterial activity compared to standard drugs streptomycin and penicillin. Further, the fluorinated derivative was found to have more antibacterial activity compared to the nitro derivative. Conclusion: Monosubstitution of electron withdrawing groups at the oxadiazole moiety is an effective approach for improving the potency of the 3-[5-(4-substituted) phenyl-1, 3, 4-oxadiazole-2yl]- 2-styrylquinazolin-4(3H)-one scaffold.

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    Author(s) Name:

    Sunusi Hudu Hantsu, Vivek Gupta*, Rakesh Narang

    Affiliation(s) Name:

    School of Pharmaceutical Sciences, Lovely Professional University, Punjab 144411

     *Corresponding author: Vivek Gupta ,Associate Professor, School of Pharmaceutical Sciences, Lovely Professional University, Punjab 144411

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    Author:

    Sunusi Hudu Hantsu, Vivek Gupta*, Rakesh Narang

    Title:Synthesis and Antibacterial Activity of Novel 3-[5-(4-substituted) phenyl-1,3,4-oxadiazole-2yl]-2-styrylquinazolin-4(3H)-ones
    Journal:Journal of Pharmacy Research
    Vol(issue):11(9)
    Year:2017
    Page No: (1122-1126)
  • Experimental Methods Keywords

    Methodology:Antibacterial activit
    Research Materials:3-[5-(4-substituted) phenyl-1,3,4-oxadiazole-2yl]-2- styrylquinazolin-4(3H)-ones

Keywords

3-(5-(4-nitrophenyl)-1 3 4-oxadiazol-2-yl)-2-styrylquinazolin-4(3H)-one 3-(5-(4-fluorophenyl)-1 3 4-oxadiazol-2-yl)-2-styrylquinazolin-4(3H)-one Antibacterial activity Oxadiazole Quinazolinone

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