Journal: Journal of Pharmacy Research

Article Id: JPRS-ND-00001822
Title: Relationship between the concentration of total proteins and specific activity of catalase in indomethacin-ulcerated rats pre-treated with Anacardium occidentale methanol leaf extract
Category: Natural Drugs
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    Background and Aim: Increased needs for proteins and anti-oxidants are required to promote wound healing; hence, this research was originated to investigate the relationship between the concentration of total proteins and specific activity of catalase in indomethacin-ulcerated rats pre-treated with A. occidentale methanol leaf extract. Materials and Methods: The effects of the methanol leaf extract of A. occidentale on the concentration of total proteins and specific activity of catalase were determined and assayed, respectively, using standard methods. Results: The extract at the three doses (100, 200, and 400 mg/kg body weight [b.w]) caused significant (P < 0.05) and dose-related increases in the concentration of total proteins and specific activity of catalase in the rats of the test groups compared to those of the rats in the ulcer-untreated group (Group 2). The 400 mg/kg b.w of the extract exerted the greatest effects in a manner similar to those of the standard anti-ulcer  drug, famotidine at the dose of 50 mg/kg b.w. Conclusion: The remarkable amelioration of the amount of total proteins and specific activity of catalase in the ulcerated rats by the methanol leaf extract of A. occidentale encourages the local utilisation of the leaves of the plant in the treatment of gastric ulcer.

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    Author(s) Name:

    Christian E. Odo

    Affiliation(s) Name:

    Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, PMB 7267  Umuahia, Abia State, Nigeria


    *Corresponding author: Christian E. Odo, Department of Biochemistry, College of Natural Sciences, Michael Okpara University of Agriculture, Umudike, PMB 7267 Umuahia, Abia State, Nigeria.

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    Author:

    Christian E. Odo

    Title:Relationship between the concentration of total proteins and specific activity of catalase in indomethacin-ulcerated rats pre-treated with Anacardium occidentale methanol leaf extract
    Journal:Journal of Pharmacy Research
    Vol(issue):11(9)
    Year:2017
    Page No: (1055-1058)
  • Experimental Methods Keywords

    Methodology:Catalase, Gastric ulcer, Proteins
    Research Materials:Anacardium occidentale

Keywords

Anacardium occidentale Catalase Gastric ulcer Proteins

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