Journal: Drug Invention Today

Article Id: JPRS-PS-00001827
Title: In vivo antiplasmodial evaluation of syzygium jambos L. Alston by four day suppressive test
Category: Pharmacological Screening
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    Objective: The unexplored region of Western Ghats possesses natural source of noble therapeutic floras for many diseases. The present study was aimed to investigate the in vivo antiplasmodial activity of Syzygium jambos from Western Ghats. Methods: The four extracts acetone, chloroform, methanol and aqueous were explore their antiplasmodial activity by Peter’s four day test. Results: In Peter’s four day test significant parasite suppression 99.24% (P<0.001) was observed in Chloroquine (CQ 25mg/kg b.wg.) group prolonging the mean survival time of animals ≥30 days, whereas no average parasitaemia suppression (44.33±0.94) was observed in the negative control group. An effective parasite suppression (P<0.01) of 72.93% and 72.18% was identified in methanol and acetone extracts respectively at 600 mg/kg b.wt. The acetone and methanol extracts prolonged the mean survival days of mice groups up to 27.8 ± 0.68 and 26.0 ± 1.29 days respectively. Conclusion: Among the four extracts tested methanol and acetone extracts exhibited antimalarial activity. The present study report establishes, Syzygium jambos leaf extracts were effective with an assorted range of antiplasmodial activity and could be a potential source in the discovery of antimalarial drug.

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    Author(s) Name:

    J Devakumar, S S Sudha*

    Affiliation(s) Name:

    PG and Research Department of Microbiology, Dr. N.G.P. Arts and Science College, Coimbatore - 641 048, Tamil Nadu, India.


    *Corresponding author: Dr. S. S. Sudha, PG and Research Department of Microbiology, Dr. N.G.P. Arts and Science College,Coimbatore - 641 048, Tamil Nadu, India

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    Author:

    J Devakumar, S S Sudha*

    Title:In vivo antiplasmodial evaluation of syzygium jambos L. Alston by four day suppressive test
    Journal:Drug Invention Today
    Vol(issue):9(2)
    Year:2017
    Page No: (19-23)
  • Experimental Methods Keywords

    Methodology: Antiplasmodial activity
    Research Materials:Syzygium jambos

Keywords

Antiplasmodial activity Chloroquine Syzygium jambos Western Ghats

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