Journal: Drug Invention Today

Article Id: JPRS-PS-00001830
Title: Evaluation of combined wound healing activity of ethanolic extracts of leaves of Murraya koenigii and Nyctanthes arbortristis on rats
Category: Pharmacological Screening
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    Objective: The present work was executed to evaluate the wound healing potency of a combined preparation of two plant extracts. The objective of this study is to induce experimental wounds using excision and incision wound model in normal albino wistar rats and to study the wound healing activity of prepared combined formulation by comparison of changes in wound healing between experimental and placebo controlled rats. Methods: The individual ethanolic extract of Murraya koenigii and Nyctanthus arbortrstis was investigated for preliminary phytochemical study. Then the effect of combined ointment formulation containing equal quantity of ethanolic extracts of leaves of Murraya koenigii and Nyctanthus arbortrstis was investigated by using excision and incision wound model in rats. Results: Both the extracts show presence of phytochemicals responsible for wound healing activity. The herbal ointment formulation 3 was found to be significantly reducing wound area, epithelization period and wound contraction rate. Similarly this formulation also shows significant increase in wound breaking strength. Conclusions: The study shows capability of both the extracts to promote accelerated wound healing activity by dose dependant manner when compared with placebo control.

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    Author(s) Name:

    V. S. Jadhav*, V. B. Ghawate

    Affiliation(s) Name:

    Department of Pharmacognosy, Mula Education Society’s College of Pharmacy, Sonai, Newasa, Ahmednagar - 414 105,Maharashtra, India


    *Corresponding author: V. S. Jadhav, Department of Pharmacognosy, Mula Education Society’s College of Pharmacy, Sonai,Newasa, Ahmednagar - 414 105, Maharashtra, India

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    Author:

    V. S. Jadhav*, V. B. Ghawate

    Title:Evaluation of combined wound healing activity of ethanolic extracts of leaves of Murraya koenigii and Nyctanthes arbortristis on rats
    Journal:Drug Invention Today
    Vol(issue):9 (September )
    Year:2017
    Page No: (24-27)
  • Experimental Methods Keywords

    Methodology:Excision wound model, Incision wound model
    Research Materials:Murraya koenigii, Nyctanthes arbortristis

Keywords

Excision wound model Incision wound model Murraya koenigii Nyctanthes arbortristis wound healing

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