Journal: Inter. J. of Chemical and Analytical Science

Article Id: JPRS-AC-00001852
Title: Comparative study of analytical method development of fluconazole in tablets and capsule by ultraviolet spectrophotometric method
Category: Analytical Chemistry
Section: Research Article
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    Objective: This comparative study is aimed to develop and validate a simple, accurate, economic, and precise ultraviolet (UV) spectroscopic method for tablets and capsules of fluconazole. Percentage purity of fluconazole in tablets and capsule was determined using bracketing method. Method: The method involves the use of easily available inexpensive solvents that is distilled water. UV-visible spectrophotometer (Shimadzu, model 1800) which has two matched quartz cells with 1 cm light path and a detection wavelength of 261 nm using a UV detector. Results: A linear response was observed over the concentration range 5-25 μg/mL of fluconazole. Detection limit for fluconazole tablet and capsule was found to be 0.894 and 1.35, respectively. Quantitation limit for fluconazole tablet and capsule was found 2.71 and 4.1, respectively. The percentage purity was found 101.35% and 97.29% for tablet and capsule, respectively. Conclusion: The comparative study of proposed method gives analytical results which satisfy all validation parameters for both tablet and capsules. The method was successfully validated in accordance to ICH guidelines acceptance criteria for linearity, accuracy, precision, robustness, and ruggedness. Good precision and accuracy which prove the reliability of proposed method in different dosage form. Hence, this method can be used routinely for quantitative estimation of fluconazole in solid dosage form (tablet and capsule) by UV spectrophotometer. The literature survey revealed that various research works are done with fluconazole in bulk, tablet, capsule, and any other formulations. The present work gives detail account on comparative study of tablet and capsule for analytical method development and validation.

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    Author(s) Name:

    Shital S. Patil*, Ubhale Ravindra, Yeole Tejal, Tayade Laxmi, P. A. Salunke, R. S. Wagh, S. D. Barhate

    Affiliation(s) Name:

    Department of Quality Assurance, Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner,Maharashtra, India

    *Corresponding author: Shital S. Patil, Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner,Maharashtra, India

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    Author:

    Shital S. Patil*, Ubhale Ravindra, Yeole Tejal, Tayade Laxmi, P. A. Salunke, R. S. Wagh, S. D. Barhate

    Title:Comparative study of analytical method development of fluconazole in tablets and capsule by ultraviolet spectrophotometric method
    Journal:Inter. J. of Chemical and Analytical Science
    Vol(issue):7 (Jan to December)
    Year:2017
    Page No: (1-6)
  • Experimental Methods Keywords

    Methodology:Analytical method validation; Bracketing method; Ultraviolet spectrophotometric method
    Research Materials: Fluconazole

Keywords

Analytical method validation; Bracketing method; Fluconazole; Ultraviolet spectrophotometric method

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