Journal: Journal of Pharmacy Research

Article Id: JPRS-P'Col-00001864
Title: The role of If and ICa,L in α-adrenergic regulation of rats cardiac activity
Category: Pharmacology
Section: Research Article
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    Aim: A heart has a very effective receptor system that interacts with mediators and activates intracellular signaling systems. Adrenoreceptors (AR) are common receptors in a man’s body. They are distinguished by a variety of functional responses arising from their activation. The currents activated by hyperpolarization (If) and the potential-dependent L-type Ca2+ channels (ICa,L) play an important role in a heart rhythm development. However, their change in ontogenesis can lead to the changes in the work of cardiovascular system. The purpose of this study was to study the effect of α-AR regulation on the chronotropic function of adult rat hearts. Materials and Method: A series of in vivo experiments was performed on the study of adult rat heart chronotropic function. The right femoral vein was administered with phenylephrine - a non-selective α-AR agonist at the dose of 0.1 mg/kg, ZD 7288 - the preparation blocking If at the dose of 0.07 mg/kg, and verapamil - the blocker of ICa,L at the dose of 0.1 mg/kg. Result and Discussion: The results indicate that the non-selective α-AR phenylephrine agonist causes a significant decrease in the cardiac activity of rats. Phenylephrine against the background of If ZD-7288 blocker causes a significant two-phase decrease in the heart rate. Conclusion: The introduction of phenylephrine against the background of ICa,L verapamil blocker action causes a significant decrease in the cardiac activity of rats.

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    Author(s) Name:

    Anna Mihailovna Kuptsova*, Nafisa Ilgizovna Ziyatdinova, Timur Lvovich Zefirov

    Affiliation(s) Name:

    Department of Man’s Health Protection, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia

    *Corresponding author: Anna Mihailovna Kuptsova, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kremlyovskaya Street 18, Kazan, Russia.

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    Author:

    Anna Mihailovna Kuptsova*, Nafisa Ilgizovna Ziyatdinova, Timur Lvovich Zefirov

    Title:The role of If and ICa,L in α-adrenergic regulation of rats cardiac activity
    Journal:Journal of Pharmacy Research
    Vol(issue):11 (Oct )
    Year:2017
    Page No: (1270-1273)
  • Experimental Methods Keywords

    Methodology:Currents activated at hyperpolarization, L-type potential-dependent calcium channels, Rat, α-adrenoreceptors
    Research Materials:Chronotropy,

Keywords

Chronotropy Currents activated at hyperpolarization L-type potential-dependent calcium channels Rat α-adrenoreceptors

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