Journal: Journal of Pharmacy Research

Article Id: JPRS-MB-00001911
Title: Associations of candidate genes with clinical-laboratory parameters in pregnant women with pre-eclampsia
Category: Medicine and Biology
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    Objectives: The associations of polymorphic variants of folate metabolism genes with clinical and laboratory parameters in pregnant women with pre-eclampsia (PE) were studied, depending on hereditary burden. Materials and Methods: The study group included 274 pregnant women, diagnosed with PE. Polymorphisms of the folate cycle genes (+677С>Т MТHFR [rs1801133], +1298А>С MТHFR [rs1801131], −1053С>Т ТYMS [rs699517], IVS6-68С>Т ТYМS [rs1059394], and −1122А>G ТYMS [rs2790]) were investigated, using the method of polymerase chain reaction (PCR) of DNA synthesis in real-time (real-time-PCR). Results: In the group of pregnant women with PE, without a burdened familial history, the genetic variants −1053СТТYMS and −1053ТТТYMS are associated with an increased level of proteinuria. In the group of pregnant women with PE, with a burdened familial history, the polymorphic variants −1053СТТYMS and −1053ТТТYMS, IVS6-68СТТYMS and IVS6-68ТТТYMS are associated with a higher level of glucose in blood, and the genotypes +1298СС MТHFR and +1298АСMТHFR are associated with the increased activated partial thromboplastin time (APTT). Conclusions: Thus, as a result of this study, significant associations of folate metabolism genes with increased levels of proteinuria, glucose, and APTT in groups of pregnant women with PE were established, depending on the burdened familial history

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    Author(s) Name:

    Evgeny A. Reshetnikov*, Inna N. Sorokina, Evgeny N. Krikun, Lyubov S. Orlova, Valery I. Evdokimov, Alexandr A. Dolgikov

    Affiliation(s) Name:

    Department of Medical Biological Disciplines, Belgorod State University, Belgorod 308015, Russia

    *Corresponding author: Evgeny A. Reshetnikov, Department of Medical Biological Disciplines, Belgorod National Research University, 85 Pobeda Street, Belgorod 308015, Russia.

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    Author:

    Evgeny A. Reshetnikov*, Inna N. Sorokina, Evgeny N. Krikun, Lyubov S. Orlova, Valery I. Evdokimov, Alexandr A. Dolgikov

    Title:Associations of candidate genes with clinical-laboratory parameters in pregnant women with pre-eclampsia
    Journal:Journal of Pharmacy Research
    Vol(issue):11 (December )
    Year:2017
    Page No: (1524-1527)
  • Experimental Methods Keywords

    Methodology: Folate cycle genes, Genetic polymorphism, Pregnancy, Pre-eclampsia
    Research Materials:pregnant women with pre-eclampsia

Keywords

Folate cycle genes Genetic polymorphism Pregnancy Pre-eclampsia

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