Journal: Journal of Pharmacy Research

Article Id: JPRS-MB-00001912
Title: Polymorphisms of candidate genes, associated with the risk of pre-eclampsia
Category: Medicine and Biology
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    Objectives: The associations of polymorphic variants of folate metabolism genes with the risk of pre-eclampsia (PE) were studied, depending on hereditary burden. Materials and Methods: The study group included 274 pregnant women, diagnosed with PE, and 179 women with normal gestation course. Polymorphisms of the folate cycle genes (+677С>Т MТHFR [rs1801133], +1298А>СMТHFR [rs1801131], +66А>G MТRR [rs1801394], +2756А>G MТR [rs1805087], −1053С>Т ТYMS [rs699517], IVS6-68 С>ТТYМS [rs1059394], and −1122А>G ТYMS [rs2790]) were investigated, using the method of polymerase chain reaction (PCR) of DNA synthesis in real-time (real-time-PCR). Results: In the group of pregnant women with PE, without hereditary burden, high frequencies of alleles + 2756G MTR (odds ratio [OR] = 1.61, P = 0.01) and the genotype + 2756GG MTR (OR = 7.26, P = 0.0007, pbonf = 0.0021) were revealed. Conclusions: Thus, as a result of this study, significant associations of polymorphism of the methionine synthase gene +2756A>G MTR with the risk of PE were established, depending on the burdened familial history.

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    Author(s) Name:

    Evgeny A. Reshetnikov*, Inna N. Sorokina, Irina V. Batlutskaya, Evgeny N. Krikun, Sergey P. Pahomov, Valery I. Evdokimov

    Affiliation(s) Name:

    Department of Medical Biological Disciplines, Belgorod State University, Belgorod 308015, Russia

    *Corresponding author: Evgeny A. Reshetnikov, Department of Medical Biological Disciplines, Belgorod National Research University, 85 Pobeda Street, Belgorod 308015, Russia.

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    Author:

    Evgeny A. Reshetnikov*, Inna N. Sorokina, Irina V. Batlutskaya, Evgeny N. Krikun, Sergey P. Pahomov, Valery I. Evdokimov

    Title:Polymorphisms of candidate genes, associated with the risk of pre-eclampsia
    Journal:Journal of Pharmacy Research
    Vol(issue):11(12)
    Year:2017
    Page No: (1528-1530)
  • Experimental Methods Keywords

    Methodology:Folate cycle genes, Pre-eclampsia, Pregnancy
    Research Materials: Genetic polymorphism

Keywords

Genetic polymorphism Folate cycle genes Pre-eclampsia Pregnancy

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